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Found 9 clinical trials
PROMOTE: Identifying Predictive Markers of Response for Genitourinary Cancer

carcinoma. Whenever possible, a new bone lesion or new/progressing soft tissue lesion will be chosen for biopsy as opposed to radiographically stable lesion. Patients will be enrolled in into one of several

prostate cancer metastatic
prostate specific antigen
bone scan
  • 04 Jun, 2021
  • 1 location
Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases

The FURTHER study aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone, the standard-of-care, as a palliative treatment option to relieve CIBP. This multicenter, three-armed randomized controlled trial will be performed in six hospitals in four European countries, and will …

bone metastases
bone lesion
focused ultrasound therapy
  • 24 Jan, 2021
  • 6 locations
PALbociclib Rechallenge in horMone Receptor-posItive/HER2- Negative Advanced Breast Cancer (PALMIRA)

Hormone Receptor (HR)-positive/Human Epidermal Growth Factor Receptor 2 (HER2)-negative advanced breast cancer (ABC)

human epidermal growth factor
hormone therapy
aromatase inhibitor
  • 27 Jan, 2021
  • 67 locations
Simple Bone Cysts in Kids

Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness …

  • 10 Feb, 2021
  • 25 locations
Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

This phase I trial studies the side effects and best dose of wild-type reovirus when combined with carfilzomib and dexamethasone in treating patients with multiple myeloma that has come back following treatment (relapsed) or does not respond to treatment (refractory). Chemotherapy drugs, such as dexamethasone and carfilzomib, work in different …

multiple myeloma
human immunodeficiency virus
bilateral oophorectomy
monoclonal protein
monoclonal antibody therapy
  • 19 Aug, 2021
  • 3 locations
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. …

kinase inhibitor
hormone therapy
tubal ligation
  • 15 Sep, 2021
  • 477 locations
Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more …

tumor cells
bone pain
chemotherapy regimen
  • 25 Jan, 2021
  • 6 locations
Zoledronate In the Prevention of Paget's Disease: Long Term Extension

early ZA treatment can favourably influence bone lesion development the significance of this to the patient in terms of symptoms is unclear as yet. The aim of the extension study is to keep these

  • 23 Jan, 2021
  • 19 locations
Infant and Child European Cryoablation Project ICECaP

A registry to audit the current range of applications, technical success rate, safety profile, complication rate and efficacy of cryoablation procedures being performed in children.

  • 16 Jul, 2021
  • 1 location