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Found 9 clinical trials
PALbociclib Rechallenge in horMone Receptor-posItive/HER2- Negative Advanced Breast Cancer (PALMIRA) (PALMIRA)

Hormone Receptor (HR)-positive/Human Epidermal Growth Factor Receptor 2 (HER2)-negative advanced breast cancer (ABC)

epidermal growth factor
letrozole
HER2
measurable disease
lhrh analogue
  • 90 views
  • 30 Apr, 2022
  • 51 locations
Simple Bone Cysts in Kids (SBoCK)

Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness …

  • 54 views
  • 09 May, 2022
  • 20 locations
Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases (FURTHER)

The FURTHER study aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone, the standard-of-care, as a palliative treatment option to relieve CIBP. This multicenter, three-armed randomized controlled trial will be performed in six hospitals in four European countries, and will …

bone lesion
heat
hifu
focused ultrasound therapy
metastasis
  • 16 views
  • 01 Mar, 2022
  • 2 locations
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that have spread to other places in the body. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. …

ipilimumab
pet scan
cancer
carcinoma
brain metastases
  • 351 views
  • 27 Jul, 2022
  • 171 locations
Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

This phase II trial studies how well low-dose radiotherapy works in treating bone pain in patients with multiple myeloma that has spread to the bone. Radiation therapy uses high energy x-rays, gamma rays, neutrons, protons, or other sources to kill tumor cells and shrink tumors. Low-dose radiotherapy may be more …

chemotherapy regimen
bisphosphonate
bone pain
tumor cells
  • 19 views
  • 11 Mar, 2022
  • 7 locations
Evaluation of Whole Body Examination by MRI Integrating the "Zero Time Eco" Sequence (ZTE, Pseudo-CT) for the Detection of Bone Lesions in Multiple Myeloma: Comparison With Pet / CT and Whole Body Scanner (MM-ZTE)

To assess the added value of magnetic resonance imaging (MRI) of the skeleton compared to other validated techniques for the detection of bone lesions in patients with multiple myeloma.

chemotherapy regimen
bone marrow procedure
  • 0 views
  • 04 Jun, 2022
  • 1 location
Zoledronate In the Prevention of Paget's Disease: Long Term Extension (ZiPP-LTE)

early ZA treatment can favourably influence bone lesion development the significance of this to the patient in terms of symptoms is unclear as yet. The aim of the extension study is to keep these

  • 172 views
  • 03 Feb, 2022
  • 2 locations
Infant and Child European Cryoablation Project ICECaP

A registry to audit the current range of applications, technical success rate, safety profile, complication rate and efficacy of cryoablation procedures being performed in children.

  • 0 views
  • 16 Jul, 2021
  • 1 location
Knee Related Subchondral Bone Lesions Treated With IOBP (IOBP)

The study will be a prospective, multicenter clinical study evaluating clinical and patient reported outcome measures of subjects receiving IOBP® surgical technique using Angel cPRP and BMA processing system to treat subchondral bone pathology (SBP).

  • 0 views
  • 09 Aug, 2022
  • 1 location