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Found 614 clinical trials
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (CareOnTIME)

This is a controlled, open study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on clinical, anthropometric parameters, metabolic syndrome, hormonal profile, bone status, quality of life, reproductive, sexual and psychological functions and treatment compliance in patients affected by congenital adrenal hyperplasia due to 21 …

adrenal insufficiency
metabolic syndrome
21-ohd
deficiency
prednisone
  • 56 views
  • 14 Apr, 2022
  • 1 location
99Tc-MDP Treatment for Knee Osteoarthritis

Osteoarthritis (OA) of knee is the most common form of arthritis in the world1e, and it has received growing attention in the society because of the increase of old age population, disabled people, and medical expenses from this disease. 99Tc-MDP is effective for rheumatoid arthritis. Therefore, the investigators try to …

  • 9 views
  • 30 Jan, 2022
  • 1 location
Trial of Pembrolizumab in Metastatic Castration Resistant Prostate Cancer

PERSEUS1 is an open-label, single arm, phase II trial evaluating the efficacy of Pembrolizumab in metastatic castration resistant prostate cancer (mCRPC) patients (Part A) with a biomarker enrichment stage (Part B) if efficacy is shown in part A.

tumor progression
antiandrogens
abiraterone
enzalutamide
major surgery
  • 0 views
  • 24 Jan, 2021
  • 1 location
Chronic Recurrent Multifocal Osteomyelitis - a Bacterial Cause?

Chronic recurrent multifocal osteomyelitis (CRMO) is an immune-mediated chronic inflammatory self- limiting disease with non-suppurative inflammation involving one or multiple bone foci. A bacterial etiology has not yet been proven, but the investigators hypothesize that CRMO is caused by chronic infection. Using existing knowledge of chronic infections combined with sensitive …

  • 471 views
  • 26 Feb, 2022
  • 1 location
Radiation-free Bone Imaging UTE MRI in Healthy and Diseased Patients

In summary, the investigators want to investigate whether UTE sequences are capable to replace imaging techniques involving ionizing radiation for bone imaging in the future. This would improve patient care greatly and might reduce medical imaging associated cancer risk drastically from an epidemiological standpoint. This field of research can be …

cancer
  • 0 views
  • 20 Jun, 2021
  • 1 location
Simple Bone Cysts in Kids (SBoCK)

Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness …

  • 54 views
  • 09 May, 2022
  • 20 locations
HC-1119 Versus Enzalutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

tissue disease on computed tomography (CT) scan or on magnetic resonance imaging (MRI), bone disease on radionuclide bone scans, FACT-P and EQ-5D, Brief Fatigue Inventory, and PSA. Throughout the

  • 0 views
  • 13 May, 2022
  • 53 locations
BFTAF Elderly Switch Study (BFTAF)

BACKGROUND: Current Kenya National Anti-retroviral (ARV) Guidelines and World Health Organization (WHO) Guidelines recommend first-line therapy of tenofovir disoproxil fumarate (TDF), lamivudine (3TC) and dolutegravir (DTG) for adult people living with HIV (PLHIV). This regimen has limitations, particularly for the aging PLHIV who are more likely to have pre-existing comorbidities …

  • 0 views
  • 22 Mar, 2022
  • 2 locations
Palliative UNConventional Hypofractionation Trial for Metastatic Bone Disease

This is a randomized Phase III study evaluating the efficacy of hypofractionated and dose-escalated palliative radiation therapy in metastatic bone disease (MBD). Patients will be randomized 1:1

  • 0 views
  • 03 Dec, 2021
  • 1 location
Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney Disease

recombinant human parathyroid hormone for treatment of adynamic bone disorder in patients with chronic kidney disease.

dialysis
parathyroid hormone
  • 0 views
  • 05 Jun, 2021
  • 3 locations