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Found 454 clinical trials
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals (Gluco-Feed)

In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo. Participants will undergo two identical overfeeding periods with each treatment. With the block and replace therapy, food-induced GC peak will be suppressed. Metabolic and autonomic …

Accepts healthy volunteers
  • 21 Apr, 2022
  • 1 location
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer (SOLARIS)

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

metastatic colorectal cancer
platelet count
solid tumors
  • 09 Aug, 2022
  • 884 locations
Benefit of Amlodipine in HRT Cycle for Frozen Embryo Transfer in the Correction of Uterine Pulsatility Index (AMLODIP)

Embryo implantation depends on two main factors: embryo grading quality and endometrial receptivity.Numerous tools have been suggested to evaluate these two factors. Measurement of the pulsatility index (PI) of the uterine arteries is associated with extremely low chances of pregnancy when it is high, especially higher than 3. A pilot …

Accepts healthy volunteers
  • 19 Jun, 2022
  • 1 location
Stretta Treatment in GERD After SG

To evaluate the effect and explore the mechanism of action behind the potential effect of Stretta on GERD after SG.

  • 10 Nov, 2021
  • 1 location
Cannabidiol and Focus Study (CBD-Focus) (CBD-Focus)

Cannabidiol (CBD), a non-psychoactive hemp derivative, is an attractive therapeutic target, and is most supported by the scientific community as an antiepileptic, anxiolytic, and antipsychotic. Additionally, CBD may cause alterations in aspects of health and fitness, fatigue, stress, calmness, quality of life, cognitive function, ability to maintain focus, sleep quantity, …

Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
Variability and Specificity in Reactive Stabilization Movements to Diverse Slip Perturbations

To maintain mobility as we age we must navigate a complex environment that challenges us with a range of disturbances. Unfortunately, older adults are often unsuccessful in resisting these disturbances, and fall. Falls are the greatest source of injury, and for older adults, the greatest source of injury-related death. Approximately …

Accepts healthy volunteers
  • 02 Mar, 2022
  • 1 location
Very Large Sizes in Adolescents : Tibial and Femoral EPIphysiodesis (GREPI)

The very large sizes can be very disabling and at the origin of a difficult psychological experience. Some families are in demand for a growth-curbing treatment. Currently, only hormonal treatments are offered in France but they are at the origin of many side effects. Northern European countries applied a surgical …

  • 20 Jul, 2022
  • 4 locations
Efficacy Of "Prodovite " In Athletic Performance

A novel patent-pending "Prodovite" VMP35 Multi-Nutrient-Complex (MNC), a vitamin, mineral, and phytonutrient encapsulated liquid formulation, was prepared using a novel proprietary SK713 SLP multi-lamellar non-GMO phospholipid nutrient absorption/delivery technology in a state-of-the-art multistep cGMP and NSF-certified manufacturing facility. This developmental technology is biodegradable and biocompatible. Preliminary study in our laboratory …

  • 14 Feb, 2021
  • 2 locations
The Effects of Almond Consumption on Functional Performance and Activity in Overweight Active Older Adults

The overall objective of this proposed randomized, crossover study is to determine the effect of 12 weeks of almond consumption, ingested as a snack twice daily, on energy expenditure, performance and functional related outcomes, in active, overweight, older adults, in comparison to 12 weeks of an isocaloric matched control snack. …

Accepts healthy volunteers
  • 15 Oct, 2021
  • 1 location
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy (REGAiN-1A)

The purpose of this study is to evaluate the efficacy and safety of intramuscular (IM) administration of Engensis on pain in participants with painful diabetic peripheral neuropathy (DPN) in the feet and lower legs, as compared to Placebo, as a second Phase 3, well controlled study, sufficient in supporting the …

peripheral neuropathy
glycosylated hemoglobin
diabetic peripheral neuropathy
  • 20 Jul, 2022
  • 20 locations