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Found 518 clinical trials
Early Convalescent Plasma Therapy for High-risk Patients With COVID-19 in Primary Care (the CoV-Early Study)

multicenter, double blind, randomized controlled trial in the Netherlands. Patients will be randomized between the transfusion of 300mL of convP versus regular fresh frozen plasma (FFP). Patient

  • 26 Jan, 2021
  • 11 locations
A Study of IMR-687 in Subjects With Beta Thalassemia

A Study to Evaluate the Safety and Tolerability of IMR-687 in Subjects with Beta Thalassemia

beta thalassemia
  • 25 Jan, 2021
  • 8 locations
The TAPS Trial - Fetoscopic Laser Surgery for Twin Anemia Polycythemia Sequence

This multicenter open-label randomized controlled trial is set up to evaluate the effect of fetoscopic laser surgery on the gestational age at birth for monochorionic twin pregnancies diagnosed with twin anemia-polycythemia sequence. Half op the patients will be treated with fetoscopic laser surgery, while the other half will be managed …

  • 25 Jan, 2021
  • 4 locations
A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient

This is an open-label, randomised, multicenter, Mircera-controlled, parallel-group, Phase III study to determine whether subcutaneous administered efepoetin alfa is as effective and well tolerated as subcutaneous Mircera for anaemia correction and maintenance in erythropoiesis stimulating agent (ESA)-nave subjects who have CKD and are not on dialysis. ESA prior users who …

  • 26 Jan, 2021
  • 40 locations
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA

Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss. Most were small, single-centre trials with considerable methodologic limitations. It is important to emphasize that none of these RCTs has included women …

cesarean section
tranexamic acid
placenta previa
  • 25 Jan, 2021
  • 1 location
Gastroschisis Outcomes of Delivery (GOOD) Study

The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we will complete a …

  • 09 May, 2021
  • 17 locations
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth

Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family. In many settings, when a mother dies in childbirth, her infant has less than a 20% chance of surviving past the first month. PPH, …

  • 25 Jan, 2021
  • 6 locations
S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

The Purpose of the study is to test the hypothesis that administration of an S-nitrosylating (SNO) agent can improve tissue oxygenation during transfusion of packed red blood cells (RBCs).

  • 11 Feb, 2021
  • 1 location
RH Genotype Matched RBC Transfusions

To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

  • 21 Mar, 2021
  • 1 location
Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates

The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who

continuous positive airway pressure
oxygen supplementation
assisted ventilation
  • 07 Nov, 2020
  • 2 locations