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Found 270 clinical trials
Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia

Aplastic anemia is a rare autoimmune disorder in which the bone marrow production of blood cells is greatly decreased or absent. Symptoms include fatigue, weakness, tiny reddish-purple marks on the skin, abnormal bruising, and bleeding from the gums, nose, or intestine. While some cases of aplastic anemia are caused by …

aplastic anemia
platelet count
reticulocyte count
neutrophil count
severe aplastic anemia
  • 07 Nov, 2020
  • 1 location
A Taiwan Isoflavone Multicenter Study (TIMS)

Consumption of soy-based foods is associated with a number of health benefits, including lower risk of cardiovascular disease, breast and prostate cancer, attenuated menopausal symptoms and prevention of bone loss with age. In order to investigate the effect of isoflavone on bone mineral density (BMD) and in Taiwan women with …

bone mineral density
cardiovascular disease
  • 07 Nov, 2020
  • 2 locations
Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study)

The investigators aim to assess the safety and efficacy of nebulized liposomal amphotericin B (ALN) as a complementary therapy to the usual systemic treatment in patients with invasive pulmonary aspergillosis and the utility of a non-routine test as a surrogate marker of efficacy. To this end, a 3-year phase I, …

  • 13 Feb, 2021
  • 1 location
Efficacy and Tolerance of an Ovarian Stimulation Protocol Combining Follicle Stimulating Hormone (FSH) and Degarelix Acetate in Female Candidates for Fertility Preservation Before Chemotherapy for Breast Cancer

The present investigation aims to evaluate the efficacy of an innovative protocol of controlled ovarian stimulation for breast cancer patients, who are candidates for fertility preservation. Currently, vitrification of oocytes and/or embryos after controlled ovarian stimulation is the most established method for female fertility preservation. However, this stimulation induces an …

adjuvant chemotherapy
ductal carcinoma
breast cancer
follicle stimulating hormone
  • 26 Apr, 2021
  • 1 location
Suicide Re Attempts in Young Adults After First Suicide Attempt : Socio-demographic Clinical and Biological Correlates

Suicide is the second leading cause of death among people aged 15 to 24 (WHO, 2014). After a first suicide attempt, the 18 to 25 years old would be very likely to repeat the act: 25 to 31% would make a new attempt in the following year (Christiansen et al, …

  • 18 Feb, 2021
  • 1 location
CyberKnife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer

The purpose of this study is to determine the side effects and how effective CyberKnife stereotactic ablative body radiation (SABR) is in patients with prostate cancer. The CyberKnife system is a new type of radiation machine that uses a special system to precisely focus large doses of x-rays on the …

bone scan
hormone therapy
endocrine therapy
  • 08 Nov, 2020
  • 1 location
Proof-of-concept Study of Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma

Some cancers of the oesophagus and stomach express excessive copies of either the cMYC (Myelocytomatosis oncogene) gene, the HER2 (Human epidermal growth factor receptor 2) gene or both. These genes may potentially contribute to the growth and spread of cancer.Ibrutinib is a drug that is already used in the treatment …

  • 23 Jan, 2021
  • 1 location
Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study

Essential tremor (ET) is the most common movement disorder in the United States and affects up to 5% of the population. ET patients experience involuntary shaking of the hands, head and/or voice that can range from mildly limiting to severely disabling. Treatment options are limited and there are currently no …

hand tremor
movement disorder
brain stimulation
  • 25 Feb, 2021
  • 1 location
Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women

The goal of this clinical research study is to evaluate a method involving a blood test, called CA-125, that may be helpful in the early detection of ovarian cancer in women who are at low risk

cancer chemotherapy
cancer of the ovary
cancer antigen 125
  • 23 Jan, 2021
  • 11 locations
Interest of Circulating Tumor DNA in Digestive and Gynecologic/Breast Cancer

Circulating tumor DNA (ctDNA) offers the possibility of accessing the tumor genome from circulating blood through a simple blood test. It is currently used for diagnostic, prognostic and

  • 03 Feb, 2021
  • 1 location