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Found 255 clinical trials
Evaluation of Diagnostic Accuracy, Safety, and Cost-Effectiveness of the Non-Invasive iSIL-FFR (in SILico FFR) Method to Measure the Fractional Flow Reserve in Diagnostics of Chronic Coronary Syndromes Versus the Standard Diagnostic Modalities.

A multicentre (7 sites), post-marketing, observational trial in 350 patients, whose standard diagnostic workup for chronic coronary syndromes provided for Invasive Coronary Angiography (ICA). Medical records of a potential subject of the trial before their enrolment contain a good quality result of at least 128-slice CCTA performed up to 3 …

computed tomography angiography
acute coronary syndrome
  • 05 Jan, 2022
  • 8 locations
Archimedes Bio-degradable Bile Duct Stent Study

This is a prospective observational cohort study to assess the utility of bio-degradable bile duct stent in the drainage of bile duct. All consecutive patients who will undergo ERCP procedure for bile leaks and patients with bile duct stones and intact gall bladder will be recruited to the study. The …

  • 01 Apr, 2021
  • 1 location
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis

The purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular phenotyping, will be analysed. The results for each data will be compared in function of the disease to search …

Accepts healthy volunteers
  • 17 Dec, 2021
  • 7 locations
Genetic Determinants of the Coronary Microvascular Obstruction in PCI

Myocardial infarction (MI) remains one of the most common causes of death. Percutaneous coronary intervention (PCI) is the main treatment option to restore blood flow through the infarction-related coronary artery (IRA) in MI patients. Performing PCI significantly reduces mortality, but in 5-10% cases, PCI is complicated by the development of …

  • 14 May, 2022
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism

Background The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese. Obesity is a major health concern. Researchers want to look at fat and muscle tissue to learn more …

Accepts healthy volunteers
  • 17 Jun, 2022
  • 1 location
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology (MURDOCH)

Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease. Advances in lung MRI methods have led to the STH department handling clinical imaging referrals from local and national respiratory units. Hyperpolarised Xenon-129 gas …

  • 30 Jun, 2022
  • 1 location
Airway Remodeling During Mepolizumab Treatment (REMOMEPO)

Chronic airway changes, such as smooth muscle hypertrophy/hyperplasia, reticular basement membrane (RBM) thickening, goblet cells hyperplasia characterize severe asthma. Chronic inflammation, and especially eosinophilia and T2 cytokines are involved in these structural changes. The aim of this prospective observational study is to assess airway changes, assessed by bronchial biopsies before …

airway remodelling
  • 26 Mar, 2022
  • 1 location
LiverMultiScan Analysis of MRI Scans in HCC

This project is a pilot study to interrogate the potential of LMS as a predictive tool for the selection of therapy for HCC patients. The reliability of LMS to predict patients' response following HCC therapy will leverage on an algorithm that is built from the pool of MRI scans from …

renal function
neutrophil count
  • 24 Jan, 2021
Genetic Polymorphism and Retinopathy of Prematurity: Correlation of Clinical Presentations and Severity

Study Aim and Goals Evaluate the correlation between genetic polymorphism and ROP development To study the possibility if there are any specific genetic polymorphisms that lead to poor outcome or recurrence of ROP after treatment.

Accepts healthy volunteers
  • 03 Dec, 2021
  • 1 location
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy

To investigate the prognostic and predictive value of plasma HPV (pHPV) prior, during and after induction chemotherapy (ICT) in locally advanced squamous cell carcinoma of the anus (SCCA) or synchronous metastatic SCCA patients treated with ICT prior to definitive (chemo)radiotherapy ((C)RT) according to multidisciplinary team (MDT) conferences based decisions. Further …

  • 23 Mar, 2022
  • 1 location