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Found 27 clinical trials
Amikacin Pharmacokinetics to Optimize Dosing Recommendations in Neonates With Perinatal Asphyxia Treated With Hypothermia

As a part of a project on perinatal clinical pharmacology, the primary aim of the present project is to study amikacin pharmacokinetics (PK) and physiology in asphyxiated neonates treated with therapeutic hypothermia and to provide amikacin dosing recommendations, which will be validated prospectively. For this purpose, we aim to first …

  • 0 views
  • 08 May, 2021
  • 1 location
Risk Factors of Spontaneous Fungal Peritonitis in Cirrhotic Patients

Spontaneous bacterial peritonitis (SBP) is an infection of the peritoneal cavity with no surgically treatable intra-abdominal source of infection. Spontaneous peritonitis is a potentially fatal complication in patients with advanced liver cirrhosis. It is estimated that 10-20 % of patients with cirrhotic ascites may develop spontaneous peritonitis, which is usually …

  • 0 views
  • 21 Nov, 2021
  • 1 location
Usefulness of White Blood Cell Count (WBCC) During Infection in Geriatric Patient

In the general population, increased WBCC and neutrophil count are widely used as markers for infection during inflammatory states 1. However, 32% of geriatric patients with an infection do not develop an increase in WBCC 2. The hypothesis is that with inflammation, geriatric patients have a misadapted response of the …

  • 0 views
  • 16 Dec, 2021
  • 1 location
Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation

This is a prospective observational study that was designed with the following two Specific Aims To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with …

  • 0 views
  • 01 May, 2022
The Volume of Blood Submitted for Culture in Neonates - a Multicentre Quality Improvement Initiative. (VOB4C)

The study will examine if introducing the practice of checking the volume of blood culture samples in neonates by bedside weighing will improve the sensitivity of the test and increase

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  • 07 Jul, 2022
Sepsis Characterization in Kilimanjaro (SICK)

The aim of this study is to prospectively evaluate the barriers to care, evaluation, clinical practices, and outcomes for patients presenting with sepsis to hospitals in the Kilimanjaro Region of northern Tanzania. This will include an assessment of timing and selection of antimicrobials and administration and volume of intravenous fluids. …

antimicrobial agent
  • 0 views
  • 21 Mar, 2022
  • 1 location
T2Resistance - Detection of Resistance Related Genes

The purpose of this study is to evaluate the safety and effectiveness of the T2Resistance Panel by validating clinical performance in three study arms: Prospective arm: positive percent agreement (PPA) and negative percent agreement (NPA) against genetic determinants of resistance detected in whole blood clinical samples or isolates collected from …

  • 0 views
  • 08 Apr, 2022
  • 1 location
Treating Non-typhoidal Salmonella Bloodstream Infections in Children Under Five in DR Congo: a Cohort Study

With this study the researchers aim to provide observational data on the treatment efficacy of currently used antibiotic treatment regimens for NTS BSI in hospital-admitted children. The study is an observational cohort study where the antibiotic treatments used and treatment outcomes in the St. Luc general referral hospital in Kisantu …

  • 0 views
  • 07 Sep, 2021
  • 1 location
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

The aim of this project is to test the utility of The Gene Z device (as of 2018 Gene Z no longer being used) and other rapid identification techniques that the investigators have developed in the lab on clinically obtained bodily fluid samples taken from patients with suspected infection or …

sepsis
systemic inflammatory response syndrome
fever
antibiotics
leukocytosis
  • 85 views
  • 19 Apr, 2022
  • 1 location
nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis (nSeP)

Diagnosis of neonatal sepsis remains a challenge due to non-specific signs and diagnostic inaccuracies. Studies have shown that this could lead to overdiagnosis and overuse of antibiotic treatment, with potential long-term adverse effects. A systems approach towards diagnosing neonatal sepsis has been shown to have high accuracy in initial studies. …

antibiotic therapy
antibiotics
  • 0 views
  • 03 Mar, 2022
  • 1 location