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Found 65 clinical trials
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Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the

sickle cell disease
stroke
red blood cell disorder
cell transplantation
  • 57 views
  • 22 Dec, 2020
  • 1 location
featured
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MD) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are easier to collect and have …

anemia
aplastic anemia
anemia studies
myelodysplastic syndrome (mds)
myelodysplastic syndromes
  • 57 views
  • 22 Dec, 2020
  • 1 location
Allogeneic Blood Stem Cell Transplantation for Patients With Life-Threatening Systemic Lupus Erythematosus

erythematosus (SLE) that is resistant to standard treatment (prednisone and cyclophosphamide [Cytoxan]) into a new study to determine if they can be successfully treated with a blood stem cell

nephritis
oral cyclophosphamide
prednisone
cyclophosphamide
corticosteroids
  • 34 views
  • 07 Nov, 2020
  • 1 location
VELCADE as Maintenance Treatment in Patients With Multiple Myeloma Following Autologous Peripheral Blood Stem Cell Transplantation (PBSCT)

Protocol DSMM VIII is a multi-center, open-label study evaluating the safety and tolerability, as well as the efficacy, of maintenance treatment with VELCADE (bortezomib) in patients with multiple myeloma with detectable disease activity following tandem high-dose chemotherapy and autologous SCT. The time from SCT to the initiation of VELCADE treatment …

cell transplantation
melphalan
velcade
high dose chemotherapy
bortezomib
  • 16 views
  • 07 Nov, 2020
  • 7 locations
Zevalin With Non Myeloablative Allogeneic Stem Cell Transplantation in Patients With Non Hodgkin Lymphoma

The purpose of this study is to investigate the ability to combine a radioactive medication directly targeted against lymphoma cells with the immune effects of an allogeneic blood stem

lymphoma cell count
fludarabine
zevalin
cyclophosphamide
cell transplantation
  • 7 views
  • 07 Nov, 2020
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 12 Mar, 2021
  • 1 location
Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL

followed by total body irradiation [TBI]/high dose cytarabine [ARA-C]/melphalan-peripheral blood stem cell transplantation (TAM-PBSCT) can improve the time to treatment failure compared to CHOP

dexamethasone
ara-c
doxorubicin
cyclophosphamide
measurable disease
  • 134 views
  • 07 Nov, 2020
  • 2 locations
Etoposide and Cisplatin in Treating Young Patients With Previously Untreated High-Risk Neuroblastoma Undergoing High-Dose Chemotherapy Stem Cell Transplant and Isotretinoin

(combination chemotherapy) and giving them in different doses may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Peripheral blood stem cell transplant using

tumor cells
doxorubicin
cyclophosphamide
filgrastim
conventional surgery
  • 20 views
  • 07 Nov, 2020
  • 1 location
Evaluation of the Role of Mesenchymal Stem Cells in the Treatment of Graft Versus Host Disease

Mesenchymal stem cells (MSC) have been shown to have immunosuppressive properties. Following a bone marrow/peripheral blood stem cell transplant, a proportion of patients develop a

acute graft-versus-host disease
blood stem cell transplant
immunosuppressive agents
immunosuppression
  • 16 views
  • 07 Nov, 2020
  • 1 location
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant

myoclonus
cytarabine
cell counts
nervous
prednisone
  • 154 views
  • 26 Apr, 2021
  • 3 locations