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Found 63 clinical trials
Featured trial
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the

cell transplantation
stroke
red blood cell disorder
sickle cell disease
  • 83 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MD) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are easier to collect and have …

aplastic anemia
anemia
anemia studies
myelodysplastic syndrome (mds)
myelodysplastic syndromes
  • 75 views
  • 22 Dec, 2020
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 24 Mar, 2022
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 04 Jun, 2022
  • 1 location
Etoposide and Cisplatin in Treating Young Patients With Previously Untreated High-Risk Neuroblastoma Undergoing High-Dose Chemotherapy Stem Cell Transplant and Isotretinoin

(combination chemotherapy) and giving them in different doses may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Peripheral blood stem cell transplant using

melphalan
tumor cells
high-risk neuroblastoma
doxorubicin
filgrastim
  • 24 views
  • 07 Nov, 2020
  • 1 location
GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG (GRAPPA)

Post-transplantation cyclophosphamide (PTCY) has become increasingly popular in the haploidentical HCT setting because it overcomes the HLA-mismatch barrier and levels GVHD risk. This advantage may also prove useful in the context of unrelated donor (UD) transplantation. GVHD prophylaxis for matched unrelated donor hematopoietic cell transplantation (alloHCT) in Europe is mainly …

  • 0 views
  • 09 Jun, 2022
  • 7 locations
Obinutuzumab in cGVHD After Allogeneic Peripheral Blood Stem Cell Transplantation

This research study is studying a drug called obinutuzumab as a means of preventing chronic Graft vs. Host Disease (cGVHD).

leukemia
cell transplantation
lymphoma
ct scan
chronic graft versus host disease
  • 10 views
  • 09 Jul, 2022
  • 5 locations
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant

apheresis
MRI
cerebellar degeneration
cytarabine
spinal cord
  • 214 views
  • 11 Jul, 2022
  • 3 locations
A Blood Stem Cell Transplant for Sickle Cell Disease

sickle cell disease produce abnormal red blood cells. A blood stem cell transplant from a donor is a treatment option for patients with severe sickle cell disease. The donor can be healthy or have the

tacrolimus
sickle cell trait
tissue type
stroke
asthma
  • 71 views
  • 24 Jul, 2022
  • 1 location
HLA-Haploidentical Peripheral Blood Stem Cell Transplantation With Post-transplant Cyclophosphamide and Bortezomib

Now haplo stem cell transplant using bone marrow or peripheral blood is becoming more feasible with better regimens to prevent graft versus host disease (GVHD) like post transplant cyclophosphamide , tacrolimus, mycophenolate . Recently Bortezomib has also been shown to inhibit dendritic cells maturation and function and possesses a number …

  • 0 views
  • 02 Jan, 2022
  • 1 location