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Found 39 clinical trials
Low-Intensity Chemotherapy Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia

the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with rituximab and blinatumomab, may induce changes in body's

serum bilirubin level
chronic myeloid leukemia
dexamethasone
serum lipase
leukemia
  • 13 views
  • 19 Mar, 2021
  • 1 location
A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance

The investigators primary objective is to determine the safety and toxicity of incorporating blinatumomab into the post-allogeneic hematopoietic stem cell transplant (HSCT) maintenance setting

white blood cell count
sirolimus
dexamethasone
cancer chemotherapy
flow cytometry
  • 4 views
  • 25 Jan, 2021
  • 1 location
PETHEMA-BLIN-01/PET069014 (BLIN-01)

such as blinatumomab, which has demonstrated efficacy and safety in patients with R/R ALL and in patients with ALL and MRD+, seems to be a promising option [30-33]. Therefore, it would be

  • 1 views
  • 24 Jan, 2021
  • 11 locations
Provision of TCR T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Na ve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantation

>Assess the safety and feasibility of the addition of Blinatumomab in the early post-engraftment period in patients with CD19+ malignancy. Estimate the incidence of malignant relapse, event-free

hematologic malignancy
cell transplantation
graft versus host disease
colony stimulating factor
lymphoma
  • 189 views
  • 04 Feb, 2021
  • 1 location
TCR -depleted Progenitor Cell Graft With Additional Memory T-cell DLI Plus Selected Use of Blinatumomab in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

Patients less than or equal to 21 years old with high-risk hematologic malignancies who would likely benefit from allogeneic hematopoietic cell transplantation (HCT). Patients with a suitable HLA matched sibling or unrelated donor identified will be eligible for participation ONLY if the donor is not available in the necessary time. …

tyrosine
chemotherapy regimen
tumor cells
hematologic malignancy
cell transplantation
  • 0 views
  • 26 Jan, 2021
  • 1 location
Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Acute Lymphoblastic Leukemia

(CalichDMH). Inotuzumab attaches to CD22 positive cancer cells in a targeted way and delivers CalichDMH to kill them. Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's

monoclonal antibody therapy
combination chemotherapy
monoclonal antibodies
lymphoid leukemia
cancer
  • 38 views
  • 29 Mar, 2021
  • 1 location
Efficacy of Montelukast in Reducing the Incidence and Severity of Monoclonal Antibodies Associated Infusion Reactions

studied includes: Blinatumomab (BLINCYTO, Amgen Inc.), Daratumumab (DARZALEX, Janssen Biotech, Inc.), Elotuzumab (EMPLICIT, Bristol-Myers Squibb Company), Gemtuzumab (MYLOTARG, Pfizer Inc.), Obinutuzumab

  • 0 views
  • 25 Jan, 2021
  • 1 location
the Bispecific PSMAxCD3 Antibody CC-1 in Patients With Castration Resistant Prostate Carcinoma

This trial is a first in human (FIH) study in patients with castration resistant metastatic prostate cancer (CRPC) after failure of third-line therapy aiming to evaluate safety and efficacy of CC-1, a bispecific antibody (bsAb) with PSMAxCD3 specificity developed within DKTK. CC-1 binds to human prostate-specific membrane antigen (PSMA) on …

  • 2 views
  • 26 Jan, 2021
  • 2 locations
Observational Study of Blinatumomab

An observational study of blinatumomab safety and effectiveness, utilisation, and treatment practices.

  • 182 views
  • 04 Apr, 2021
  • 88 locations