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Found 38 clinical trials
A Study of Subcutaneous Blinatumomab Administration in Acute Lymphoblastic Leukemia (ALL) Patients

The study aims to evaluate the safety and tolerability of subcutaneous (SC) blinatumomab for treatment of Acute Lymphoblastic Leukemia (ALL) and to determine the maximum tolerated dose (MTD

  • 0 views
  • 11 Jun, 2021
  • 34 locations
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has

  • 0 views
  • 29 May, 2021
  • 107 locations
A Study of Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Acute Lymphoblastic Leukemia (ALL)

The primary objectives of this study are to evaluate the safety and tolerability of blinatumomab in combination with AMG 404 in adults with acute lymphoblastic leukemia (ALL) and to estimate the

dexamethasone
blinatumomab
lymphoid leukemia
  • 0 views
  • 13 Jun, 2021
  • 30 locations
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic

leucovorin
white blood cell count
vincristine
calcium
combination chemotherapy
  • 84 views
  • 14 Jun, 2021
  • 119 locations
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

diagnostics, but above all, qualitatively reorient the therapy. The most important consequence will be that this study is testing immunotherapy with the bispecific antibody blinatumomab as an alternative to

vincristine
residual tumor
fludarabine
blinatumomab
pegaspargase
  • 562 views
  • 26 Jan, 2021
  • 168 locations
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

Remission Induction, by the addition of molecular and immunotherapeutic approaches including tyrosine kinase inhibitors or chimeric antigen receptor (CAR) T cell / blinatumomab for refractory B-acute

tyrosine
vincristine
remission
residual tumor
vorinostat
  • 230 views
  • 29 Jan, 2021
  • 7 locations
A Treatment Study Protocol for Participants 1-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several randomised …

dexamethasone
inotuzumab
vincristine
imatinib
doxorubicin
  • 27 views
  • 27 Jan, 2021
  • 102 locations
Blinatumomab Bridging Therapy

The investigator is testing the ability of a biologically active therapy in blinatumomab, an anti-CD19/CD3 bispecific T-cell engager, to further reduce residual leukemia immediately prior to HCT

  • 0 views
  • 03 Feb, 2021
  • 1 location
Allogeneic Donor Lymphocyte Infusions Combined With Blinatumomab

This phase 2 study is designed to evaluate the safety, tolerability and efficacy of allogeneic donor lymphocyte infusions (DLI) combined with the bispecific T cell engager blinatumomab in B

tyrosine
nilotinib
bosutinib
dasatinib
imatinib
  • 6 views
  • 23 Jan, 2021
  • 2 locations
Blinatumomab Plus HLA-Mismatched Cellular Therapy for Relapsed/Refractory CD19+ ALL

Single center Phase 1 dose escalation trial of the combination of standard-of-care blinatumomab plus Haplo-Mismatched Cellular Therapy (HMCT). HMCT refers to the infusion of donor peripheral

cytopenias
blinatumomab
flow cytometry
stem cell transplantation
cellular therapy
  • 0 views
  • 14 Feb, 2021
  • 1 location