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Found 254 clinical trials
hARnessing CAbozantinib and Durvalumab Immuno-oncology Association: ARCADIA Study"

Cabozantinib plus Durvalumab in patients with advanced and chemotherapy-treated bladder carcinoma, of urothelial and non-urothelial histology: an open-label, single-centre, phase 2, single-arm

  • 0 views
  • 04 Mar, 2021
  • 1 location
A Randomized Phase III Double Blind Clinical Trial Evaluating the Effect of Immune-Enhancing Nutrition on Radical Cystectomy Outcomes

This phase III trial studies how well nutrition therapy works in improving immune system in patients with bladder cancer that can be removed by surgery. Improving nutrition before and after surgery may reduce the infections and other problems that sometimes occur after surgery.

transurethral resection
carcinoma
bladder tumor
radical cystectomy
transurethral bladder excision
  • 6 views
  • 18 Oct, 2022
  • 32 locations
Adjuvant Chemotherapy for Biliary Tract Cancer After Curative Resection

This prospective, open-Label, comparative, randomized, controlled phase III trial was designed to compare the clinical performance of gemcitabine with capecitabine vs. capecitabine alone for patients with biliary tract cancer (BTC) after curative resection.

  • 0 views
  • 22 Jan, 2021
  • 1 location
Chidamide With Immunotherapy for Patients With Locally Advanced or Metastatic Urothelial Carcinoma

Study of Chidamide Combined With Immunotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Who Had Previously Received Platinum-based Chemotherapy

  • 8 views
  • 26 Jan, 2021
  • 1 location
Pembrolizumab in MIBC

Subjects with cT2-T3N0M0 urothelial cancer of the bladder will be enrolled. After completing two cycles of pembrolizumab, subjects will undergo a restaging MRI of the abdomen and pelvis with a standard acquisition protocol (as outlined in the protocol) as well as CT chest. A CT of the abdomen and pelvis …

transurethral resection of bladder tumor
neuropathy
pembrolizumab
cancer
neutrophil count
  • 0 views
  • 07 Oct, 2022
  • 1 location
Neoadjuvant Toripalimab in Combination With Gemcitabine and Cisplatin Therapy in Local Advanced Bladder Cancer Subjects

This is a pre-surgical study involving subjects with local advanced bladder cancer, who are candidates for neoadjuvant therapy. It is a single-arm phase II portion.

gemcitabine
carcinoma
bladder tumor
measurable disease
radical cystectomy
  • 0 views
  • 21 Mar, 2022
  • 1 location
Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab (PRESERVE3)

This is a Phase 2, multicenter, randomized, open-label study evaluating the safety and efficacy of trilaciclib administered with platinum-based chemotherapy followed by trilaciclib administered with avelumab maintenance therapy compared with platinum-based chemotherapy followed by avelumab maintenance therapy in patients receiving first-line treatment for advanced/metastatic bladder cancer.

cancer
metastatic bladder cancer
gemcitabine
bladder tumor
avelumab
  • 1 views
  • 15 Jun, 2022
  • 25 locations
Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy

This trial investigates whether a one-month course of preventative (prophylactic) antibiotics helps to reduce urinary tract infections after robot-assisted surgery to remove all of the bladder as well as nearby tissues and organs (radical cystectomy). Urinary tract infections are a common occurrence after robot-assisted radical cystectomy. Antibiotics such as trimethoprim-sulfamethoxazole …

invasive bladder cancer
ertapenem
cancer
nitrofurantoin
antibiotic therapy
  • 0 views
  • 10 May, 2022
  • 1 location
Adding Mitomycin to BCG as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer (BCG+MM)

Open label, randomised phase 3 trial of the addition of Mitomycin to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer. The study aim is to compare disease-free survival between treatment arms: BCG alone versus Mitomycin in addition to BCG.

invasive bladder cancer
cancer
carcinoma in situ
mitomycin
transurethral resection
  • 16 views
  • 07 Oct, 2022
  • 14 locations
Checkpoint Inhibitor and Radiation Therapy in Bulky Node-Positive Bladder Cancer

Clinically node positive (cN+) bladder cancer carries a poor prognosis, especially in patients who are unable to receive or fail to respond to neoadjuvant chemotherapy. Immune checkpoint inhibitor (ICI) therapy is FDA-approved in advanced bladder cancer for patients unable to receive or failing to respond to platinum-based chemotherapy. The present …

atezolizumab
pembrolizumab
transurethral bladder excision
advanced urothelial carcinoma
cisplatin/gemcitabine
  • 0 views
  • 07 Oct, 2021
  • 1 location