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Found 24 clinical trials
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the

Accepts healthy volunteers
  • 0 views
  • 26 Feb, 2022
  • 11 locations
Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy

Recently, treatment with tafamidis in patients with cardiac ATTR lead to a significant reduction in mortality. The Perugini score is commonly used on planar bone scans to differentiate cardiac ATTR from other amyloidosis or normal patients but fails to evaluate amyloid burden and patient prognosis. Although semi-quantitative methods have been …

  • 0 views
  • 07 May, 2021
  • 1 location
Trochanteric Femur Fracture Operated With Dynamic Hip Screw System (DHS) Augmented With a Biphasic Apatite Sulphate Combined With Systemic or Local Bisphosphonate

bisphosphonate (Zometa) locally or systemically that affects bone metabolism. Furthermore, fracture healing and implant migration will be investigated.

  • 0 views
  • 25 Mar, 2022
  • 1 location
The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.

Osteoradionecrosis (ORN) is a severe delayed radiation-induced injury that can occur in patients whom have been subjected to radiotherapy for head and neck cancer. Hyperbaric oxygen treatment (HBO) is one treatment option. In Sweden it is used in some locations in combination to standard treatment which includes for example antibiotics, …

  • 0 views
  • 28 Jun, 2021
  • 2 locations
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE)

The overall aim of this trial, which is called STAMPEDE, is to assess novel approaches for the treatment of men with prostate cancer who are starting long-term ADT for the first time, termed hormone-naïve prostate cancer. This trial aims to see if we can improve the way in which prostate …

endocrine therapy
adenocarcinoma
neutrophil count
antiandrogen therapy
docetaxel
  • 3825 views
  • 04 May, 2022
  • 115 locations
The Effectiveness of Eldecalcitol in the Bisphosphonate Non-respondered-patients With Osteoporosis

In the patients with osteoporosis, bisphosphonates (BPs) are a golden standard treatment. However, the bone turnover markers or the bone mineral density (BMD) are not improved in some osteoporotic patients even though they have taken BPs and alfacalcidol more than several years. In those case, the investigators better off prescribing …

osteoporosis
bisphosphonate
bone mineral density
  • 85 views
  • 29 Sep, 2021
  • 1 location
Initial Management of MRONJ Stages I and II a Clinical Trial With Detection of Salivary Biomarkers

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies, such as Bisphosphonates and Denosumab. It is defined by the presence of exposed bone or a fistula that probes bone in the jaws for a period greater than 8 weeks in patient with a history …

  • 0 views
  • 24 Feb, 2021
  • 1 location
Bisphosphonates for Prevention of Post-Denosumab Bone Loss

The primary goal of the study is to assess the extent to which bisphosphonate therapy will prevent decreases in bone mass that may occur after cessation of denosumab in premenopausal women with

forteo
bisphosphonate therapy
teriparatide
osteoporosis
denosumab
  • 78 views
  • 03 Mar, 2022
Effects of Bisphosphonates on OI-Related Hearing Loss

OI-related hearing loss also present with otosclerosis and because of their mechanistic similarities, the investigators propose studying the effects of bisphosphonate treatment on individuals

bisphosphonate
hearing loss
vitamin d
risedronate oral tablet
Accepts healthy volunteers
  • 12 views
  • 24 Apr, 2022
  • 1 location
Healthy Body Healthy Bones After Bariatric Surgery Trial

massive weight loss associated with bariatric surgery adversely affects bone leads to an increased risk of fracture. Bisphosphonate medications, such as zoledronic acid, are used to treat bone loss in

osteoporosis
bisphosphonate
Accepts healthy volunteers
zoledronic acid
  • 76 views
  • 19 Nov, 2021
  • 1 location