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Found 61 clinical trials
Featured trial
Vascular Contributions to Mechanisms and Biomarkers of Alzheimer’s Disease

This study is managed by Temple University Alzheimer’s Center in collaboration with Crozer Keystone Health System. NO drug involvedThe study will evaluate longitudinally whether the presence of cardiovascular (CV) risk factors (particularly hypertension and hyperhomocysteinemia), in an age and gender-matched population including cognitive normal, subjects with mild cognitive impairment (MCI) …

mild cognitive impairment
Accepts healthy volunteers
cognitive decline
cognitive impairment
  • 09 Sep, 2022
  • 1 location
Study to Assess the Effect of Ofatumumab in Treatment Naïve, Very Early RRMS Patients Benchmarked Against Healthy Controls. (AGNOS)

resonance imaging (MRI) outcomes. The study will also assess changes in disease using monitoring techniques including digital biometric device use, biomarker analysis and non-conventional MRI. Select

Accepts healthy volunteers
  • 14 Mar, 2022
  • 1 location
JAK 1/2 Inhibitor, Baricitinib, in the Treatment of Adult IIM (MYOJAK)

This study aims to investigate the clinical efficacy of baricitinib in patients with adult idiopathic inflammatory myositis (IIM). Half of the patients enrolled onto the study will receive 24 weeks of baricitinib from the baseline visit with a 12 week follow-up period. The other half of patients will receive 24 …

a 12
  • 03 Jun, 2022
  • 1 location
Autologous Bone Marrow Concentrate in Knee Osteochondral Allograft Transplantation

The goal of this study is to establish if mesenchymal stem cell augmentation improves graft incorporation and to analyze the cytokine environment of the joint after osteochondral allograft transplantation (OCA) with and without intra-articular bone marrow aspirate concentrate (BMAC) injection. Information learned from this study can be used to biochemically …

  • 25 Mar, 2022
  • 1 location
REVEAL Biomarkers of Engraftment After Alternative Donor HSCT

The purpose of this study is to find new tests that could help determine if the newly infused bone marrow cells are growing well after bone marrow transplantation or if new bone marrow cells are needed. In this study we will use FLT imaging which is an investigational imaging test, …

  • 24 May, 2022
  • 1 location
A Pilot, Open Study to Assess Efficacy and Safety of Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated Locally Advanced/Metastatic Squamous Cell Carcinoma

This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC). Rigosertib may selectively target Epidermolysis bullosa (EB) cancer cells while leaving normal EB cells unaffected.

  • 14 Sep, 2022
  • 1 location
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes (ALLEVIATE)

Open, Single arm intervention, feasibility study

  • 09 Jun, 2022
  • 1 location
A Randomized Phase III Trial of Trastuzumab + ALpelisib +/- Fulvestrant Versus Trastuzumab + Chemotherapy in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer. "ALPHABET Study". (ALPHABET)

Randomized phase III trial of trastuzumab + Alpelisib +/- fulvestrant versus trastuzumab + chemotherapy in patients with PIK3CA mutated previously treated HER2+ Advanced Breast cancer.

  • 19 Aug, 2022
  • 54 locations
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy (REBIRTH)

The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and clinical outcomes. Given that bromocriptine prevents breastfeeding, an additional 50 women with peripartum cardiomyopathy excluded from the trial …

  • 28 Jun, 2022
  • 1 location
Study of AMG 199 in Subjects With MUC17-Positive Solid Tumors Including Gastric, Gastroesophageal Junction, Colorectal, and Pancreatic Cancers

To evaluate the safety and tolerability of AMG 199 in adult subjects and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).

  • 11 Mar, 2022
  • 21 locations