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Found 282 clinical trials
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Patients With Generalized Myasthenia Gravis

This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of satralizumab compared with placebo in participants with generalized myasthenia gravis (gMG).

generalized myasthenia gravis
  • 20 views
  • 23 Oct, 2022
  • 83 locations
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs

The purpose of this study is to evaluate the efficacy and safety of deucravacitinib versus placebo in participants with active psoriatic arthritis who are naïve to biologic disease-modifying anti-rheumatic drugs. The long term extension period will provide additional long-term efficacy and safety information.

plaque psoriasis
high sensitivity
arthritis
skin lesion
biological drug
  • 10 views
  • 07 Apr, 2023
  • 105 locations
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

The purpose of this study is to evaluate the safety and efficacy of deucravacitinib versus placebo for the treatment of participants with active PsA who are naïve to biologic disease modifying antirheumatic drugs or had previously received TNFα inhibitor treatment.The long term extension period will provide additional long-term safety and …

plaque psoriasis
high sensitivity
arthritis
skin lesion
biological drug
  • 6 views
  • 04 Apr, 2023
  • 105 locations
A Phase 3 Open-Label, Randomized Study of LOXO-305 Versus Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-321) (BRUIN CLL-321)

This is a study for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) who have previously received treatment with at least a BTK inhibitor. The main purpose is to compare LOXO-305 to idelalisib plus rituximab or bendamustine plus rituximab. Participation could last up to four years, and …

btk inhibitor
lymphoma
rituximab
idelalisib
neutrophil count
  • 5 views
  • 22 Oct, 2022
  • 208 locations
Biologics and Blistering

The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune system to injury, disease, or irritation. It is a process by which your body's white blood cells and the things they make …

atopic dermatitis
triamcinolone acetonide
allergen
antiinflammatory
patch test
  • 0 views
  • 07 Oct, 2022
  • 1 location
Boosting Biologics in Ulcerative Colitis

This study evaluates the safety of the probiotic compound IDOFORM TRAVEL® in patients with ulcerative colitis undergoing anti-TNF treatment with insufficient clinical response. Furthermore, the study aims to explore the composition of the bacteria of the gut as well as the immunological activity in patients with ulcerative colitis undergoing anti-TNF …

immunomodulators
colitis
endoscopy
inflammatory bowel disease
Accepts healthy volunteers
  • 3 views
  • 17 Oct, 2022
  • 1 location
Biologics and Partial Enteral Nutrition Study

quality of life of sufferers. Two of the best treatments currently used in people with CD are drug injections and/or infusions (biologics), and a liquid-only diet using specialised milkshakes. However

tumor necrosis factor
adalimumab
enteral nutrition
Accepts healthy volunteers
crohn's disease
  • 0 views
  • 08 Dec, 2021
  • 4 locations
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)

It is increasingly recognized that although suppression of inflammation is a treatment goal in rheumatoid arthritis, many people who have control of their inflammation continue to experience pain. A number of studies have recently shown that by measuring further characteristics of pain in rheumatoid arthritis, e.g. neuropathic pain, quantitative sensory …

leflunomide
hydroxychloroquine
sulfasalazine
methotrexate
cyclic citrullinated peptide antibody
  • 13 views
  • 26 Jan, 2021
  • 1 location
Surgery Versus Biologics for Stricturing CD--a RCT (SIBTC)

The management of stricturing Crohn's disease (CD) remains challenging. Although surgical resection may be the final way to solve it, the efficacy of biologics for symptomatic CD associated

remission
crohn's disease
  • 0 views
  • 04 Oct, 2022
  • 1 location
Evaluation of Mood Disorders Under Biologics in Chronic Inflammatory Rheumatic Disease (EMOTION)

Chronic inflammatory rheumatic diseases (CIRD) affect many organ systems. Painful sensations within the joints spine, hand and foot deformities, low quality of life and psychosocial status in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis can lead to the development of anxiety and depression. Prevalences of anxiety increase in patients …

anxiety
depressed mood
depression
  • 0 views
  • 18 Apr, 2022
  • 1 location