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Found 278 clinical trials
A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Patients With Metastatic Colorectal Cancer

This is a global, randomized, double-blind, placebo-controlled, multicenter phase 3 clinical trial to compare the efficacy and safety of fruquintinib plus best supportive care (BSC) versus placebo plus BSC in patients with refractory metastatic colorectal cancer (mCRC). 687 subjects will be randomized to one of the following treatment arms in …

biological therapy
oxaliplatin
fluoropyrimidine
regorafenib
cancer
  • 0 views
  • 04 Feb, 2021
  • 33 locations
Ileal Crohn's Disease and Post-operative Outcome: Prospective Cohort Study of the REMIND Group

Crohn's disease (CD), a chronic inflammatory process in intestinal segments leads to tissue damage. More than two thirds of CD patients need intestinal resection. Symptomatic clinical recurrence occurs in 60% by 10 years. The principal factors affecting postoperative recurrence are active smoking, penetrating disease, perianal lesions history, prior intestinal resection, …

tumor necrosis factor
mercaptopurine
luminal
tumour necrosis
thiopurines
  • 9 views
  • 26 Jan, 2021
  • 17 locations
Effect of EITC on Biological Markers of Aging Health and Mortality

Paycheck Plus (PP) is a randomized controlled experiment (RCT) that explores the health and longevity effects associated with increasing the Earned Income Tax Credit (EITC). EITC is a national program that provides tax credits to low-income, disproportionately minority workers who file taxes. EITC is politically popular, having received bipartisan support. …

  • 0 views
  • 03 Feb, 2021
  • 1 location
Biologically Modified Saphenous Vein Transplants for Improved CABG Outcomes

The purpose of this study is to study the effects of polyarginine treated vein grafts on graft patency for patients undergoing coronary artery bypass surgery.

hmg-coa reductase inhibitor
  • 112 views
  • 22 Jan, 2021
  • 1 location
Clinical and Biological Database in Colon Cancer and Colic Tumors

Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.

  • 3 views
  • 25 Jan, 2021
  • 3 locations
Predictive Clinical and Biological Parameters in Breast Cancer

Research of predictive clinical and biological factors in breast cancer : genomic, proteomic, mutation

  • 0 views
  • 21 Jan, 2021
  • 3 locations
Biological Dating of Cerebral Ischemia With GST- /PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis

The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase- (GST-) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with neurological deficiency of less than 12 hours.

infarct
cerebral infarction
ischemia
  • 8 views
  • 28 Jan, 2021
  • 8 locations
Rivaroxaban or Aspirin for Biological Aortic Prosthesis

Aortic valve replacement with a biological prosthesis is the most common valve surgery performed with about 1000 operations performed in Denmark each year. Further, the introduction of percutaneous stent valves will increase these types of replacements in the years to come. A biological valve is a foreign body prone to …

rivaroxaban 10 mg
clot
infarct
stroke
warfarin
  • 0 views
  • 22 Jan, 2021
  • 3 locations
Predictive Clinical and Biological Parameters in Acute Leukemia Myelodysplastic Syndromes and Myeloproliferative Disorders-HEMATO-BIO-IPC-2013-015

HEMATO-BIO-IPC-2013-015 is a monocenter prospective longitudinal study. Our aim is to define predictive clinical and biological factors in acute leukemia, myelodysplastic syndromes and myeloproliferative disorders by using genomics, genetics and epigenetics, in vitro and in vivo drug sensitivity studies,and translational immonulogy and immunomonitoring studies. HEMATO-BIO primary outcome measure is to …

cancer
acute leukemia
bone marrow procedure
myeloproliferative disorder
biological factors
  • 13 views
  • 22 Jan, 2021
  • 1 location
Development of a Clinical and Biological Database in Peritoneal Carcinosis (BCB CARCINOSE)

The creation of a prospective clinical-biological base dedicated to peritoneal carcinosis must therefore be able to serve as a support for this essential search for transfer.

primary cancer
  • 2 views
  • 26 Jan, 2021
  • 1 location