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Found 266 clinical trials
Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

Through scientific and rigorous design, implementation, follow-up and statistics, the sponsor aims to explore the clinical efficacy and safety of Tislelizumab combined with chemotherapy (platinum + paclitaxel) in the treatment of patients with bone metastases cancer with unknown primary, and provide a better treatment plan for these patients. Primary outcome: …

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Effect of Tofacitinib on Coagulation and Platelet Function, and Its Role in Thromboembolic Events

Post-authorization, prospective and unicenter clinical trial, in which patients with UC will be included. The treatment with anti-TNFα (infliximab, adalimumab or golimumab) or JAK-inhibitors (tofacitinib) will be initiated by clinical practice and the choice will be made at the discretion of the investigator at the center where the patients will …

golimumab
infliximab
corticosteroids
adalimumab
vedolizumab
  • 0 views
  • 04 Oct, 2022
  • 1 location
Identification of Predictive Biomarkers for Response to Biologic Therapies in Inflammatory Bowel Disease

Prospective, multicentre trial which the biologic treatment will be initiated by clinical indication. The treatment selection anti-TNF (infliximab, adalimumab or golimumab), vedolizumab and ustekinumab will be made at the discretion of the clinician. There will be no random assignment of treatment. The drugs will be used in the approved indications …

tumor necrosis factor alpha
vedolizumab
immunosuppressive agents
ustekinumab
tumor necrosis factor
  • 32 views
  • 03 Sep, 2021
  • 19 locations
Advanced Sensor Based Functional ASsessmenTs in Axial Spondyloarthritis

This is an observational study using Inertial Measurement Unit (IMU) sensors to measure the effects of biological therapy on spinal mobility and function in axial spondyloarthritis. Participants

MRI Scan
biological therapy
  • 0 views
  • 16 Oct, 2021
  • 1 location
People-Powered Medicine (PPM): Rheumatoid Arthritis Non-responders to Biologic Therapies (RANT) (PPM:RANT)

The investigators are interested in enrolling patients with rheumatoid arthritis (RA) who had a difficult time getting their disease under control even after trying multiple RA therapies. The investigators believe that there may be common patterns in the genes of this group of RA patients compared to those with more …

tumor necrosis factor
tumour necrosis
  • 0 views
  • 04 Oct, 2022
  • 1 location
Can we Rely on HLA to Predict Resistance to Biological Therapy in IBD Patients

The investigators propose an observational study including patients with inflammatory bowel disease under biological therapy with anti-TNF, anti-integrin or anti-interleukin 12-23 (Ustekinumab

enteropathy
tumor necrosis factor
ustekinumab
  • 0 views
  • 27 Sep, 2021
  • 1 location
Advanced Therapy Registry of IBD Patients

The study is aim to detect common microbial profiles and metabolic pathways throughout IBD diagnosis and treatment with biological therapy.

pouchitis
remission
  • 0 views
  • 04 Oct, 2022
  • 1 location
Italian Registry of Arthritis on Biologic Therapy (GISEA)

The biologic drugs targeting TNFa, IL-6, IL-1, T cells, B cells have represented a fundamental discovery to treat rheumatic patients whose disease appears to be refractory to conventional therapy. These biologic drugs have been registered for human therapy from a few years, thereby the investigators miss long-term data for safety …

rheumatic diseases
tumor necrosis factor alpha
leflunomide
psoriatic arthritis
spondyloarthropathy
  • 7 views
  • 01 Mar, 2022
  • 1 location
Spanish Registry of Systemic Treatments in Psoriasis (Biobadaderm)

The purpose of Biobadaderm is a to study the safety of systemic therapy in psoriasis.

systemic therapy
  • 45 views
  • 18 Apr, 2022
  • 13 locations
Descriptive Study of the Incidence of Malignancy in Severe Asthma Patients Receiving Benralizumab and Other Biologic Therapy, a Post Authorization Safety Study

This is a real-world, observational, prospective cohort study in patients with severe asthma recruited into the International Severe Asthma Registry (ISAR) and the US severe asthma registry (CHRONICLE) and followed-up for occurrence of new malignancies. The primary objective is to measure the incidence of malignancy in the overall severe asthma …

primary cancer
  • 0 views
  • 22 Oct, 2022
  • 2 locations