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Found 255 clinical trials
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Advanced Colorectal or Lung Cancer Screening

Advanced Colorectal or Lung Cancer Screening

  • 158 views
  • 25 Mar, 2021
  • 1 location
AScalate: Treat-to-target in Axial Spondyloarthritis

biological therapy and who have had an inadequate response to non-steroidal anti-inflammatory drugs. The study will include an 8-week Screening period, a 36-week treatment period according to previous

MRI
spondylitis
adalimumab
secukinumab
NSAID
  • 1 views
  • 04 Apr, 2021
  • 44 locations
Standard of Care Therapy With or Without Stereotactic Radiosurgery and/or Surgery in Treating Patients With Limited Metastatic Breast Cancer

, biological therapy, and others may help stop the spread of tumor cells. Radiation therapy and/or surgery is usually only given with standard of care therapy to relieve pain; however, in patients with limited

hormone therapy
primary tumor
pain reliever
epinephrine
biomarker analysis
  • 574 views
  • 10 Mar, 2021
  • 84 locations
Breast Cancer: Axillary Conservation After Neoadjuvant Chemotherapy in Micro Metastatic Sentinel Lymph Nodes.

Italian multicentric non inferiority clinical study to verify whether the omission of axillary lymph node intervention in patients with SLN (Sentinel Lymph Nodes) ypN1mi after NAC (Neo Adiuvant Chemotherapy) does not lead to a significant deterioration in survival or in the risk of regional or distant recurrence, compared to patients …

breast carcinoma
metastasis
carcinoma
axillary lymph node dissection
invasive breast cancer
  • 2 views
  • 30 Apr, 2021
  • 1 location
A Study of the Efficacy and Safety of Upadacitnib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and severely active Crohn's disease (CD).

immunosuppressive agents
conventional treatment
endoscopy
mucosal inflammation
corticosteroids
  • 824 views
  • 07 Apr, 2021
  • 694 locations
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis

moderate psoriasis. Eligibility People ages 18-70 with mild to moderate active psoriasis not currently treated with biological therapy Design

vitamins
body mass index
niacin
  • 50 views
  • 07 May, 2021
  • 1 location
First-in-human Study of CA102N Monotherapy and of CA102N Combined With Trifluridine/Tipiracil (LONSURF) in Subjects With Advanced Solid Tumors

Study HS-CA102N-101 is a phase 1, two part (dose escalation, dose expansion), multicenter, non-randomized, open-label, multiple dose, first-in-human study of CA102N monotherapy and of CA102N combined with trifluridine/tipiracil (LONSURF) in subjects with advanced solid tumors. CA102N will be evaluated in subjects with locally advanced or metastatic solid tumours for which …

  • 1 views
  • 25 Jan, 2021
  • 3 locations
A Comparative Study of MRI US and CE for Assessing Treatment Response in Known Crohn's Disease

The aim of this study is to evaluate non-invasive imaging techniques for assessing treatment response in known Crohn's disease. Comparing imaging modalities: The applicability of small bowel colon capsule endoscopy (SBCCE), magnetic resonance enterocolonography (MREC) and ultrasound (US) for diagnosing ulcer healing after medical treatment in patients with symptomatic Crohn's …

ulceration
endoscopy
corticosteroids
capsule endoscopy
crohn's disease
  • 5 views
  • 24 Jan, 2021
  • 1 location
Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study

CABATEN is a multicohort phase II study of cabozantinib plus atezolizumab in advanced and progressive tumors from endocrine system. The primary objective is to assess the efficacy of cabozantinib plus atezolizumab combination by means of radiological objective response rate (ORR) evaluated following RECIST v1.1 criteria in advanced endocrine tumors. Endocrine …

measurable disease
neuroendocrine carcinoma
liver metastasis
somatostatin
biological therapy
  • 0 views
  • 26 Jan, 2021
  • 14 locations
Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA. Interleukin-1 (IL-1) levels in the human knee joint increase transiently after an …

  • 0 views
  • 15 May, 2021
  • 1 location