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Found 49 clinical trials
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Safety Tolerability and Pharmacokinetics of Oral NX-13 in Active Ulcerative Colitis

This is a Phase 1b, randomized, double-blind, multicenter dose-ranging study to evaluate the safety, tolerability, and PK of NX-13. Approximately 40 subjects will be randomized in a 3:3:3:1 ratio to receive 1 of 3 NX-13 treatment regimens (NX-13 250 mg IR, 500 mg IR, 500 mg MR) (12 evaluable subjects …

aminosalicylates
faecal calprotectin
  • 0 views
  • 11 Nov, 2021
  • 32 locations
None
Combination of Baricitinib and Adalimumab in Rheumatoid Arthritis

As stated by the European League Against Rheumatism (EULAR) and the Societe Francaise de Rhumatologie (SFR), treatment of patients with rheumatoid arthritis (RA) should target sustained remission or at least low disease activity. However, despite significant advances based on various combinations of conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and biologic …

corticosteroids
abatacept
adalimumab
rituximab
methotrexate
  • 0 views
  • 21 Jul, 2021
  • 20 locations
None
An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

, loss of response, or intolerant to conventional or biologic therapy for UC.

mirikizumab
  • 1755 views
  • 12 Nov, 2021
  • 881 locations
None
Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA. Interleukin-1 (IL-1) levels in the human knee joint increase transiently after an …

  • 0 views
  • 15 May, 2021
  • 1 location
None
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

The investigators will be administering oral high dose interval vitamin D, concurrently when participants are receiving biologic therapy for their inflammatory bowel disease. The investigators

indeterminate colitis
colitis
vitamin
enteropathy
ulceration
  • 0 views
  • 16 Jun, 2021
  • 1 location
None
COmbinAtion Therapy of dieT With biologicalS for Crohn's Disease: the OATS Study

This study is a randomised open label study, comparing the FIT diet with standard diet in patients with Crohn's disease treated with biologic therapy.

faecal calprotectin
ileitis
combination therapy
crohn's disease
abdominal pain
  • 0 views
  • 06 Oct, 2021
  • 1 location
None
CIML NK Cell in Head & Neck Cancer

This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the

neck cancer
oropharyngeal
caries
combination drug
head and neck cancer
  • 0 views
  • 16 Aug, 2021
None
An Efficacy Study of Secukinumab In Enthesitis of Psoriatic Arthritis Patients

arthritis patients. This study will be the first randomized trial of a biologic therapy in participants with psoriatic arthritis, using imaging test.

arthritis
secukinumab
biological drug
enthesitis
psoriasis
  • 0 views
  • 28 Jul, 2021
  • 1 location
None
Microbiome Modification to Enhance Stelara Response in Crohn's Disease

-serine diet (vs. a high serine diet) will improve responses in patients initiating therapy with Ustekinumab (Stelara), an FDA-approved biologic therapy for Crohn's disease.

ustekinumab
prednisone
crohn's disease
  • 0 views
  • 04 Jun, 2021
  • 1 location
None
Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Ulcerative Colitis (UC)

planning to switch biologic therapy or undergo colectomy as the next stage in their treatment plan.

  • 0 views
  • 18 Feb, 2021
  • 1 location