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Found 40 clinical trials
Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis (ELEFTA)

(NSAIDs), have not received biologic therapy or targeted Disease-modifying antirheumatic drugs (DMARDs).

  • 0 views
  • 22 Jul, 2022
  • 2 locations
Combination of Baricitinib and Adalimumab in Rheumatoid Arthritis (CRI-RA)

As stated by the European League Against Rheumatism (EULAR) and the Société Française de Rhumatologie (SFR), treatment of patients with rheumatoid arthritis (RA) should target sustained remission or at least low disease activity. However, despite significant advances based on various combinations of conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and biologic …

abatacept
prednisone
methotrexate
remission
anakinra
  • 0 views
  • 15 Mar, 2022
  • 6 locations
An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

, loss of response, or intolerant to conventional or biologic therapy for UC.

mirikizumab
  • 1999 views
  • 10 Mar, 2022
  • 36 locations
Biologic Therapy to Prevent Osteoarthritis After ACL Injury

Anterior cruciate ligament (ACL) injuries are extremely common. On average, 50% of individuals suffering an ACL injury will develop radiographic osteoarthritis (OA) 10 to 20 years after injury. Unfortunately, ACL reconstruction does not prevent risk of future OA. Interleukin-1 (IL-1) levels in the human knee joint increase transiently after an …

Accepts healthy volunteers
autograft
osteoarthritis
acl injuries
breakdown
  • 0 views
  • 11 Jul, 2022
  • 1 location
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy

The investigators will be administering oral high dose interval vitamin D, concurrently when participants are receiving biologic therapy for their inflammatory bowel disease. The investigators

indeterminate colitis
infliximab
ulceration
colitis
vitamin
  • 0 views
  • 08 Aug, 2022
  • 1 location
COmbinAtion Therapy of dieT With biologicalS for Crohn's Disease: the OATS Study

This study is a randomised open label study, comparing the FIT diet with standard diet in patients with Crohn's disease treated with biologic therapy.

faecal calprotectin
abdominal pain
ileitis
crohn's disease
combination therapy
  • 0 views
  • 06 Oct, 2021
  • 1 location
CIML NK Cell in Head & Neck Cancer

This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the

neutrophil count
neck cancer
combination drug
head and neck cancer
caries
  • 0 views
  • 05 May, 2022
An Efficacy Study of Secukinumab In Enthesitis of Psoriatic Arthritis Patients

arthritis patients. This study will be the first randomized trial of a biologic therapy in participants with psoriatic arthritis, using imaging test.

secukinumab
biological drug
enthesitis
methotrexate
plaque psoriasis
  • 8 views
  • 28 Jul, 2021
  • 1 location
Microbiome Modification to Enhance Stelara Response in Crohn's Disease (MIM-TESRIC)

-serine diet (vs. a high serine diet) will improve responses in patients initiating therapy with Ustekinumab (Stelara), an FDA-approved biologic therapy for Crohn's disease.

ustekinumab
crohn's disease
prednisone
  • 0 views
  • 03 Jun, 2022
  • 1 location
Study of Mesenchymal Stem Cells for the Treatment of Medically Refractory Ulcerative Colitis (UC) (UC)

planning to switch biologic therapy or undergo colectomy as the next stage in their treatment plan.

enemas
infliximab
monoclonal antibodies
colectomy
certolizumab pegol
  • 1 views
  • 18 Apr, 2022
  • 1 location