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Found 16 clinical trials
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A Multiple-Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3041658 in Patients with Neutrophilic Skin Diseases

A Multiple-Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3041658 in Patients with Neutrophilic Skin Diseases

  • 470 views
  • 25 Mar, 2021
  • 1 location
Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)

cyclophosphamide in refractory idiopathic scleritis. There is no firm evidence or randomized controlled trials directly addressing the best biologic agent in severe and refractory idiopathic scleritis. If left

  • 0 views
  • 24 Jan, 2021
  • 1 location
Effect of Hyaluronic Acid on Gingival Recession Treatment

stability Hyaluronic acid (HA) is one such biologic agent that demonstrates future for periodontal regeneration. It is a major component of the extracellular matrix in almost all tissues. The primary role

  • 0 views
  • 28 Jan, 2021
  • 1 location
Safety and Efficacy of rAAV.hCNGA3 Gene Therapy in Patients With CNGA3-linked Achromatopsia

The purpose of this study is to proof the safety and efficacy of a single bilateral subretinal injection of rAAV.hCNGA3 in adult and minor patients with CNGA3-linked achromatopsia.

  • 0 views
  • 10 Apr, 2021
  • 1 location
Pilot Study Assessing the Effect of Tildrakizumab in Vitiligo

Vitiligo is a common acquired depigmentation disorder affecting approximately 2% of the world population. The purpose of this pilot study is to evaluate the effect and the safety of Tildrakizumab in adult participants with vitiligo.

hypopigmentation
  • 0 views
  • 28 Jul, 2021
  • 1 location
Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients

starting on a new biologic agent (infliximab, adalimumab, golimumab, vedolizumab). The overall objective is to (1) evaluate the efficacy, safety and tolerability of phentermine-topiramate, and (2

  • 0 views
  • 05 Feb, 2021
  • 1 location
Using Adalimumab Serum Concentration to Choose a Subsequent Biological DMARD in Rheumatoid Arthritis Patients Failing Adalimumab Treatment

A potential application of therapeutic drug monitoring is to predict efficacy after switch to another biological in the case of inefficacy of the previous TNF-inhibitor (TNFi) in rheumatoid arthritis (RA) patients. It has been shown that when antidrug antibodies against adalimumab are detected (resulting in lower drug serum concentrations) in …

DMARD
tumor necrosis factor
methotrexate
leflunomide
adalimumab
  • 3 views
  • 22 Jun, 2021
  • 2 locations
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders

Rheumatoid arthritis (RA) is the most common inflammatory rheumatoid disease in France, affecting 0.3% of the general population. Without effective treatment, the persistent inflammation causes invalidating pain and joint destruction, leading to major functional disability. Biological agents have been proposed for patients with RA who have the most severe form …

tumor necrosis factor inhibitors
antirheumatics
DMARD
tocilizumab
tumor necrosis factor
  • 7 views
  • 22 Jan, 2021
  • 1 location
Study on the Safety for the Newborn of the Use of Biologics During Pregnancy by Mothers Affected by Autoimmune Diseases

The goal of the study is to evaluate the effects on the offspring and therefore the safety of using biologic agents during pregnancy and their eventual consequences on children. The effects considered are divided into peri-partum and more long-term effects. Demonstration of safety in children born from mothers who received …

  • 0 views
  • 23 Jan, 2021
  • 1 location
Follow-Up Study of Subjects Previously Enrolled in Poxviral Vector Gene Transfer Studies

to introduce specific genes into genetic makeup. The study does not involve the use of any drug or biologic agent. Participants will undergo an annual health history. Because certain viruses enter

metastasis
primary malignant neoplasm
metastases
cancer
  • 7 views
  • 31 Jul, 2021
  • 1 location