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Found 199 clinical trials
Surveys Blood Testing and Fibroscan in Screening for Liver Fibrosis and Liver Cirrhosis

This clinical trial studies the use of surveys, blood testing, and fibroscan in screening for liver fibrosis and liver cirrhosis in new or existing patients of the HOPE clinic seeking usual clinical care. Fibroscan is an imaging procedure of the liver which uses a probe like an ultrasound. Information gathered …

  • 0 views
  • 15 Mar, 2021
  • 1 location
A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

> This study will enroll 7 tumor-specific cohorts: urothelial bladder cancer, biliary tract cancer, cervical cancer, endometrial cancer, ovarian cancer, pancreatic cancer, and rare tumors.

  • 0 views
  • 19 Jun, 2021
  • 93 locations
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

cancer (TNBC), ovarian cancer, gastric cancer, colorectal cancer (CRC), glioblastoma (GBM), biliary tract cancers (BTC), or pancreatic cancer. All participants will be enrolled into initial tumor

colorectal neoplasm
lenvatinib
solid tumour
pembrolizumab
stereotactic biopsy
  • 611 views
  • 21 Jun, 2021
  • 82 locations
Pre- vs Postoperative Thromboprophylaxis for Liver Resection

Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when thrombosis prophylaxis should be commenced in patients undergoing liver surgery. As far as we know, there are no prospective randomized trials …

tinzaparin
dalteparin
thromboembolism prophylaxis
thrombosis
clot
  • 0 views
  • 15 Jun, 2021
  • 6 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

measurable disease
NTRK
tyrosine
lung cancer
lung carcinoma
  • 0 views
  • 03 Jun, 2021
  • 195 locations
A Study to Test the Safety of the Investigational Drug Selitrectinib in Children and Adults That May Treat Cancer

This research study is done to test the safety of the new drug selitrectinib in children and adults with cancer having a change in a particular gene (NTRK1, NTRK2 or NTRK3). The drug may treat cancer by interfering with the effect of the NTRK genes on cancer growth. The study …

NTRK
solid tumor
kidney function tests
fibrosarcoma
renal function tests
  • 1310 views
  • 20 Jun, 2021
  • 79 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

human immunodeficiency virus
platelet count
erdafitinib
tubal ligation
white blood cells
  • 6087 views
  • 20 Jun, 2021
  • 1017 locations
Pembrolizumab in Biliary Tract Cancer

This is a single-arm, multi-centre, phase II study in biliary tract cancer (BTC) patients. The main objective is to detect an increase in progression-free survival rate at 6 months (according to

platelet count
anticoagulants
biliary tract carcinoma
gemcitabine
symptom control
  • 78 views
  • 25 Mar, 2021
  • 7 locations
Molecular Profiling of Advanced Biliary Tract Cancers

Biliary tract cancer (BTC) accounts for <1% of all cancers, but remains a highly fatal malignancy. Surgical resection is the only hope for cure, but most patients present with advanced

measurable disease
advanced biliary tract carcinoma
biliary cancer
palliative care
gemcitabine
  • 0 views
  • 05 Mar, 2021
  • 1 location
AZD6738 Plus Durvalumab in Biliary Tract Cancer

This trial will enroll advanced biliary tract cancer patients who have been previously treated with immunotherapy in either the 2nd or 3rd line. Patients will be treated with AZD6738 and

platelet count
hysterectomy
azd6738
durvalumab
intrahepatic bile duct carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location