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Found 215 clinical trials
The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer

The extent of hepatic resection for gallbladder cancer can be done from a wedge resection to 4b/5 bisegmentectomy. This study aims to compare the recurrence rates and survival rates between wedge resection group and bisegmentectomy group. Patients with T2 or T3 gallbladder cancer on preoperative CT exam or patients who …

  • 32 views
  • 21 Jan, 2021
  • 1 location
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers (POLCAGB)

Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care. Randomized trials have shown survival benefit with combination chemotherapy in gallbladder cancers. Gallbladder cancer is not common western world and thus there is lack of evidence regarding …

residual disease
gemcitabine/cisplatin
laparoscopy
cholecystectomy
gallbladder disease
  • 38 views
  • 01 Feb, 2022
  • 1 location
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

Background Bile duct cancer is cancer of the slender tubes of the biliary tract. These tubes carry bile through the liver. Such cancer tumors often have an abnormal or mutated gene. Researchers think a mix of drugs can slow the progression of gene-mutated cancers of the biliary tract. Objective To …

EGFR
hydroxychloroquine
measurable disease
KRAS
cancer
  • 0 views
  • 27 May, 2022
  • 1 location
  • 4 views
  • 06 Feb, 2022
  • 16 locations
The Purpose of This Trial is to Determine if Regorafenib Plus Durvalumab (MEDI4736) is Safe and Effective in Treatment of Chemo Refractory Advanced Biliary Tract Cancers

The purpose of this study is to measure how effective combining Durvalumab and Regorafenib will be for participants with advance stage biliary track carcinoma who have received one line of prior treatment

  • 0 views
  • 14 Apr, 2022
  • 5 locations
Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

biliary tract cancer that has spread to the peritoneum (peritoneal metastases). PIPAC involves the administration of intraperitoneal chemotherapy (anticancer drugs given directly to the lining of the

paclitaxel
measurable disease
gemcitabine
cancer
ct scan
  • 0 views
  • 06 May, 2022
  • 1 location
A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors

This is a Phase 1/2, open-label, multicentric, non-randomised, parallel-arm study that aims to establish the safety, tolerability, and initial efficacy of CAN04 in combination with 3 SoC chemotherapies (mFOLFOX, DTX, and G/C).

cancer chemotherapy
targeted therapy
measurable disease
EGFR
carcinoma
  • 0 views
  • 18 Nov, 2021
  • 5 locations
An Open-label, Phase I/II Study of PLENA Regimen in Patients With Unresectable Pancreatic Cancer or BTC

biliary tract cancer (BTC) remain to have proven value, highlights the urgency for designing novel therapeutic strategies to combat these deadly diseases. The immunomodulatory effect of lenvatinib

paclitaxel
measurable disease
unresectable pancreatic cancer
  • 0 views
  • 01 May, 2022
  • 1 location
Single Session Combined Locoregional Therapies for Hepatocellular Carcinoma

Hepatocellular carcinoma is the third most common cause of cancer-related mortality. In recent years, transarterial chemoembolization, radio frequency ablation and microwave ablation have been accepted as treatment modalities for patients with surgically unresectable hepatocellular carcinoma.

carcinoma
chemoembolization
platelet count
radiofrequency ablation
hepatocellular carcinoma
  • 6 views
  • 22 Jan, 2021
  • 1 location
The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis

Previous data have suggested that vitamin D levels may influence cancer development. In particular, several single nucleotide polymorphisms have been described in the Vitamin D receptor( VDR gene), and some polymorphisms are associated with tumor occurrence. For instance, VDR polymorphisms have been related to cancers of the breast, prostate, skin, …

hepatitis
cirrhosis
  • 4 views
  • 22 Jan, 2021
  • 1 location