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Found 201 clinical trials
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Study of Pembrolizumab Following TACE in Primary Liver Carcinoma

Open label, single arm, multi-centre study of pembrolizumab following trans-arterial chemoembolization (TACE). Twenty-six to 32 evaluable participants with primary liver cancer (hepatocellular cancer; HCC) will be assessed. The primary objective is to determine the safety and tolerability of pembrolizumab following TACE. The secondary objective is to evaluate the efficacy of …

  • 0 views
  • 22 Feb, 2021
  • 1 location
None
Liposomal Irinotecan Fluorouracil Leucovorin Calcium and Rucaparib in Treating Patients With Metastatic Pancreatic Colorectal Gastroesophageal or Biliary Cancer

treating patients with pancreatic, colorectal, gastroesophageal, or biliary cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as liposomal irinotecan

calcium
measurable disease
vasectomy
fluorouracil
leucovorin
  • 8 views
  • 30 Aug, 2021
  • 4 locations
None
Apatinib for Advanced Biliary Carcinoma

This is a phase II open-label, one-arm, single-center study of apatinib for eligible patients with advanced biliary tract carcinoma after the first-line treatment failure. A total of 55 patients is planned for enrollment. The time for enrollment is from Nov 2017 to Nov 2020, the the follow-up will be ended …

renal function
apatinib
measurable disease
advanced biliary tract carcinoma
mitomycin
  • 15 views
  • 22 Jan, 2021
None
Study of TRIFLURIDINE/TIPIRACIL in Previously Treated Cholangiocarcinoma

This is a multi-centre, open-label, single arm phase 2 study to assess the efficacy of TRIFLURIDINE/TIPIRACIL, in patients with advanced cholangiocarcinoma as measured by median progression-free survival (PFS). This study will enroll a total of 47 patients over a 12-month period, according to a two stage enrollment design. Nine patients …

renal function
measurable disease
liver metastasis
trifluridine/tipiracil
extrahepatic cholangiocarcinoma
  • 58 views
  • 27 Oct, 2021
  • 1 location
None
Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC

chemotherapies in the treatment of participants with previously untreated locally advanced or metastatic biliary tract cancer. The primary hypothesis of this study is that participants will have a longer

cancer
cholangiocarcinoma
oxaliplatin
systemic therapy
biliary tract cancer
  • 8 views
  • 29 Mar, 2021
  • 1 location
None
CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization

This trial studies the use of computed tomography (CT) perfusion scans in detecting changes in blood flow to the liver after portal vein embolization in patients with liver cancer. CT perfusion scans use a standard contrast drug given by vein to measure blood flow to the liver. CT perfusion scans …

  • 0 views
  • 22 Jan, 2021
  • 1 location
None
Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers

Locally advanced Gall bladders cancers not amenable for curative resection are often treated with chemotherapy alone which is the current standard of care. Randomized trials have shown survival benefit with combination chemotherapy in gallbladder cancers. Gallbladder cancer is not common western world and thus there is lack of evidence regarding …

gemcitabine/cisplatin
jaundice
residual disease
gallbladder disease
laparoscopy
  • 38 views
  • 22 Jan, 2021
  • 1 location
None
Comparing the Current Hydration Regimen for the ABC02 Chemotherapy Regimen Versus a Shorter Hydration

This is an open label study for any patients with a bile duct cancer or gallbladder cancer, who will be treated with gemcitabine and cisplatin chemotherapy (the ABC02 regime). Patients recruited onto this study will have a reduction of their hydration time and be given Akynzeo as an anti-sickness drug, …

cancer
cholangiocarcinoma
renal function
gemcitabine
carcinoma
  • 4 views
  • 13 Mar, 2021
  • 1 location
None
The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer

The extent of hepatic resection for gallbladder cancer can be done from a wedge resection to 4b/5 bisegmentectomy. This study aims to compare the recurrence rates and survival rates between wedge resection group and bisegmentectomy group. Patients with T2 or T3 gallbladder cancer on preoperative CT exam or patients who …

  • 32 views
  • 21 Jan, 2021
  • 1 location
None
Study of LM-102 in Patients With Advance Solid Tumors

gastric cancer/gastroesophageal junction adenocarcinoma, Pancreatic Cancer, Biliary Tract Cancer, esophageal adenocarcinoma and ovarian mucous carcinoma.

  • 0 views
  • 19 Nov, 2021
  • 1 location