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Found 220 clinical trials
Toripalimab Plus Lenvatinib as Second-line Treatment in Advanced Biliary Tract Cancers

The investigators design a phase II clinical study to explore the efficacy and safety of toripalimab plus lenvatinib as a second-line treatment in patients with advanced biliary tract cancers

  • 0 views
  • 26 Jan, 2021
  • 1 location
Immunotherapy Combined With Y-90 SIRT Therapy in Advanced Stage Intrahepatic Biliary Tract Cancer (BTC)

CTLA-4 Inhibitor Tremelimumab in patients with intrahepatic Biliary Tract Cancer

serum bilirubin
biliary tract cancer
durvalumab
renal function
metastasis
  • 1 views
  • 06 May, 2022
  • 3 locations
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene

cancer
tumor cells
oophorectomy
olaparib
absolute neutrophil count
  • 0 views
  • 29 May, 2022
  • 5 locations
Tislelizumab(Anti PD-1), Lenvatinib and GEMOX Transformation in the Treatment of Potentially Resectable, Locally Advanced Biliary Tract Cancer

The aim of this study is to assess the R0 resection rate of tislelizumab combined with Lenvatinib and Gemox chemotherapy in the conversion therapy of potentially resectable locally advanced BTC.

  • 0 views
  • 19 Dec, 2021
  • 1 location
Metabolic Stress-induced Exercise to Prevent Loss of Muscle Mass in Patients With Pancreatic and Biliary Tract Cancer (PREV-Ex)

pancreatic and biliary tract cancer, versus usual care on skeletal muscle and other health-related outcomes.

resectable pancreatic cancer
  • 0 views
  • 18 Apr, 2022
  • 1 location
Adjuvant Capecitabine vs Gemcitabine Plus Cisplatin in Resected Extrahepatic Cholangiocarcinoma

There is no proven adjuvant treatment after curative surgical resection in patients with cholangiocarcinoma, although previous meta-analysis suggested potential survival benefit of adjuvant chemotherapy or radiotherapy in patients with lymph node-positive resected cholangiocarcinoma. Despite of lack of level 1 evidence and no data which regimen is optimal, adjuvant chemotherapy is …

absolute neutrophil count
renal function
serum total bilirubin
gemcitabine
extrahepatic cholangiocarcinoma
  • 15 views
  • 24 Feb, 2022
  • 1 location
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

treating patients with pancreatic, colorectal, gastroesophageal, or biliary cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as liposomal irinotecan, fluorouracil

parp inhibitor
tumor cells
progesterone
rucaparib
metastatic adenocarcinoma
  • 8 views
  • 16 Jun, 2022
  • 3 locations
Apatinib for Advanced Biliary Carcinoma

This is a phase II open-label, one-arm, single-center study of apatinib for eligible patients with advanced biliary tract carcinoma after the first-line treatment failure. A total of 55 patients is planned for enrollment. The time for enrollment is from Nov 2017 to Nov 2020, the the follow-up will be ended …

carcinoma
renal function
apatinib
measurable disease
mitomycin
  • 15 views
  • 26 Feb, 2022
  • 1 location
Study of TRIFLURIDINE/TIPIRACIL in Previously Treated Cholangiocarcinoma (MOCHA)

This is a multi-centre, open-label, single arm phase 2 study to assess the efficacy of TRIFLURIDINE/TIPIRACIL, in patients with advanced cholangiocarcinoma as measured by median progression-free survival (PFS). This study will enroll a total of 47 patients over a 12-month period, according to a two stage enrollment design. Nine patients …

liver metastasis
gallbladder cancer
biliary tract cancer
renal function
gemcitabine
  • 58 views
  • 01 Mar, 2022
  • 1 location
Programmed Death Ligand (PD-L1) Combined With Chemotherapy for Patients With BTC (KN035-BTC)

chemotherapies in the treatment of participants with previously untreated locally advanced or metastatic biliary tract cancer. The primary hypothesis of this study is that participants will have a longer

biliary tract cancer
systemic therapy
oxaliplatin
recurrent disease
measurable disease
  • 8 views
  • 14 Jul, 2022
  • 1 location