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Found 37 clinical trials
A Phase 2a/2b Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in Adult Women With Intrahepatic Cholestasis of Pregnancy and Elevated Serum Bile Acid Concentrations (OHANA). (OHANA)

This is a two-part randomized study of volixibat in patients with Intrahepatic Cholestasis of Pregnancy (ICP) and elevated serum bile acid concentrations (sBA). Part 1 is an open-label study to

  • 15 views
  • 28 Oct, 2022
  • 20 locations
Efficacy and Safety of Obeticholic Acid in the Treatment of Primary Biliary Cholangitis

Obecholic acid is a modified bile acid and Farnesoid X receptor (FXR) agonist. FXR is a key regulator of bile acid synthesis and transport. Bile acids are used by the body to help with digestion

  • 0 views
  • 04 Oct, 2022
  • 1 location
Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients (ACAV)

treated with adequate doses of statins to achieve desirable reduction of LDL-C levels (reduction ˂ 60% of LDL-C). The use of alternative lipid-lowering drugs including bile acid sequestrates, fibrates

  • 1 views
  • 10 May, 2022
  • 1 location
Impact of Beef on Metabolites and Inflammation

Western omnivore diets tend to use beef as a good source of protein. Studies have shown cattle who are fed different diets results in varying nutritional meat profiles in terms of amino acids, types and relative amounts of fat, and other nutrients. While overlap between organic and conventionally raised beef …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Effect of UDCA on the New Onset Diabetes and Glucose Intolerance Induced by Statin-A Multicenter, Prospective, Random Controlled Trial

the levels of glycosylated hemoglobin, insulin and C-peptide increased significantly with the extension of follow-up time in patients with hyperlipidemia. At the same time, serum and fecal bile acid

  • 0 views
  • 16 Oct, 2022
  • 1 location
Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)

functions and hepatic synthesis and fecal excretion of bile acids in patients with diarrhea associated with bile acid malabsorption (BAM).

  • 0 views
  • 10 May, 2022
  • 1 location
Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk

to which the relationship between diet (independent variable) and mucosal markers of CRC risk including epithelial proliferation, oxidative stress, DNA damage, and primary and secondary bile acid

Accepts healthy volunteers
colon cancer
  • 4 views
  • 04 Oct, 2022
  • 1 location
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer (Bridge CRC)

A Mediterranean Diet (MedDiet), a largely plant-based dietary pattern, is relevant to CRC prevention and microbial production of anti-cancer metabolites in observational studies. A MedDiet can shift BA metabolism as shown in primates and when combined with calorie restriction, shows superior adherence and weight control in humans, given its palatability. …

Accepts healthy volunteers
  • 13 views
  • 01 May, 2022
  • 1 location
Study of Obeticholic Acid OCA Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC)

Obecholic acid is a modified bile acid and Farnesoid X receptor (FXR) agonist. FXR is a key regulator of bile acid synthesis and transport. Bile acids are used by the body to help with digestion

biopsy of liver
bile acid
obeticholic acid
antimitochondrial antibody
  • 5 views
  • 01 Aug, 2021
  • 1 location
Impact of Foods on Bile Acids, Metabolites, and Inflammation

increases bile acid secretion and excretion, which will decrease toxicity linked to excess accumulation of bile in the liver, improve metabolism, and lower resulting levels of bile acids in the serum. In

fatty liver
Accepts healthy volunteers
bile acid
fasting
body mass index
  • 0 views
  • 20 Apr, 2022
  • 1 location