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Found 6 clinical trials
Bexarotene Treatment in Schizophrenia

In this proposed study, we aim to investigate the effects of Bexarotene (Targretin; LGD1069; 4-[1-{5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl} ethenyl] benzoic acid) on

cognitive impairment
antipsychotics
  • 11 views
  • 07 Nov, 2020
  • 2 locations
Preoperative Bexarotene Treatment for Cushing's Disease

The objective of this pilot study is to establish the safety and tolerability of short-term therapy with bexarotene in patient's with Cushing's disease, and study the clinical

cushing's syndrome
ACTH
dexamethasone suppression test
hypercortisolism
free cortisol
  • 42 views
  • 07 Nov, 2020
  • 1 location
Study of IRX4204 With Erlotinib in Previously Treated Advanced NSCLC

Patient selection: a) Pathological confirmation of non-small cell lung cancer without activating EGFR mutations; b) Advanced stage disease (IV or IIIB with malignant effusion) with at least two prior chemotherapy regimens; c) No available curative therapy; d) Pregnant women are excluded; e) Informed consent. Pretreatment evaluation: a) Medical history and …

cancer chemotherapy
neutrophil count
ct scan
growth factor
tyrosine
  • 12 views
  • 24 Jan, 2021
  • 1 location
The Role of Bexarotene in Inducing Susceptibility to Chemotherapy in Metastatic TNBC

Triple-negative breast cancer (TNBC) is biologically aggressive and has limited systemic treatment options, often compounded by treatment resistance. Cell state transitions, e.g. epithelial-to-mesenchymal transition (EMT) govern cancer cell behaviour. The investigators hypothesize that by inducing change in cell state change, TNBC cells that have manifested taxane-resistance will be more sensitized …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Bexarotene Tretinoin and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

RATIONALE: Bexarotene and tretinoin may cause tumor cells to look more like normal cells, and to grow and spread more slowly. Drugs used in chemotherapy, such as cisplatin, carboplatin

docetaxel
stage iv non-small cell lung cancer
combination chemotherapy
metastasis
carboplatin
  • 5 views
  • 07 Nov, 2020
  • 1 location
A Pilot of a Microdevice For In Situ Candidate Drug Screening in Cutaneous Lesions of T-Cell Lymphoma

This research is being done to study the safety of implanting and retrieving a microdevice that releases up to 19 drugs directly within a cancerous lesion as a possible tool to evaluate the effectiveness of several approved cancer drugs against cutaneous T cell lymphoma and peripheral T cell lymphoma

cancer
neutrophil count
systemic therapy
vorinostat
romidepsin
  • 0 views
  • 25 Jan, 2021