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Found 28 clinical trials
Temocillin Pharmacokinetics in Paediatrics (TEMOPEDI)

Temocillin (6-methoxy-ticarcillin) is a beta-lactam antibiotic with exceptional resistance to most beta-lactamases. In this context, it is now increasingly used as carbapenem-sparing antibiotic

temocillin
antibiotics
antibiotic prophylaxis
cirrhosis
antibiotic therapy
  • 7 views
  • 15 Jun, 2022
  • 1 location
Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

to examine the effects of two commonly used antibiotics (the beta-lactam, amoxicillin and the macrolide azithromycin) on human microbial populations and on metabolic and immune physiology, studying

Accepts healthy volunteers
  • 0 views
  • 27 Jun, 2022
  • 1 location
Phase 1 Oral QPX7831 SAD and MAD in Healthy Adults

This Phase 1 study will assess the safety, tolerability, and pharmacokinetics (PK) of QPX7831, a beta-lactamase inhibitor, when administered orally in single ascending doses and in multiple ascending doses to heathy adult subjects.

tubal ligation
beta-lactamase inhibitor
body mass index
hysterectomy
Accepts healthy volunteers
  • 0 views
  • 05 May, 2022
  • 1 location
Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections (TANGOKIDS)

A single dose infusion of Vabomere (meropenem-vaborbactam) is being tested for dose-finding, pharmacokinetics, safety, and tolerability in pediatric subjects from birth to less than 18 years of age with serious bacterial infections

absolute neutrophil count
renal function
antibiotics
antibiotic therapy
  • 5 views
  • 26 Jan, 2022
  • 5 locations
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery

BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay. The appropriate and timely use of prophylactic antibiotics is found to reduce the prevalence of SSIs. At present, several regimen of …

Accepts healthy volunteers
  • 0 views
  • 15 Jun, 2022
  • 1 location
Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units (Pop-PK/PD)

Antibiotics are still most often administered on an empiric fashion, as defined for the general population with dosages only adapted based on weight and renal and/or hepatic functions. As a result, serum concentrations show important interpatient variations with the risk of being subtherapeutic or toxic. Recent studies with temocillin, ceftriaxone, …

pulmonary infection
antibiotics
renal function
ceftriaxone
antibiotic therapy
  • 30 views
  • 04 Jun, 2022
  • 1 location
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients (TEMODELTA)

Multidrug resistance towards Gram-negative pathogens makes essential the re-examination of older compounds. Temocillin is a penicillin originally marketed in the 1980s but then largely abandoned. It, however, shows a marked ß-lactamase stability (including most classical and extended-spectrum TEM, SHV, CTX-M enzymes and AmpC ß-lactamase). Temocillin is approved for the treatment …

antibiotics
bacteremia
abdominal infection
  • 0 views
  • 20 Jun, 2022
  • 1 location
Antimicrobial Prophylaxis in Patients Who Underwent a Transurethral Resection of Bladder (TURB)

Antimicrobial prophylaxis in urological procedures is aimed to reduce the risk of local and systemic postoperative infections such as urinary tract infection or surgical site infection. It should be recommended only when the potential benefit exceeds the anticipated risks and costs. However, a wide variation in the use of periprocedural …

antibiotics
urine culture
amikacin
fosfomycin
antimicrobials
  • 9 views
  • 23 Jan, 2021
  • 1 location
The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring

Little is known of beta-lactam antibiotics' true therapeutic plasma concentration range. The aims of this study are to define evidence-based, safe and effective upper and lower limits of the

  • 0 views
  • 02 Jun, 2021
  • 1 location
Clinical Comparison of Treatment Strategies in AmpC Beta-lactamase Producing Enterobacterales in a Swiss Tertiary Care Hospital (AmpCstratBasel)

This study is to investigate the recent epidemiological trends and the treatment outcome in terms of the length of hospital stay, the relevant renal and neurological side effects, risk factors for developing these side effects, the selection of more resistant pathogens under therapy as well as the incidence of Clostridium …

  • 0 views
  • 23 Mar, 2022
  • 1 location