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Found 24 clinical trials
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections

Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta

  • 29 views
  • 21 Feb, 2022
  • 1 location
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy

Buruli ulcer (BU) is a skin Neglected Tropical Disease (NTD) that is caused by Mycobacterium ulcerans. It affects skin, soft tissues and bones causing long-term morbidity, stigma and disability. The greatest burden falls on children in sub-Saharan Africa. Treating BU requires 8-weeks with daily rifampicin and clarithromycin, wound care, and …

  • 0 views
  • 08 Jan, 2022
  • 3 locations
Efficacy of Extended Infusion of β-lactam Antibiotics for the Treatment of Febrile Neutropenia in Hematologic Patients (BEATLE)

This study evaluates the administration of beta-lactam antibiotics in extended infusion in hematological patients with febrile neutropenia after 5 days of treatment. The beta-lactam antibiotics

antibiotic therapy
stem cell transplantation
leukemia
neutrophil count
meropenem
  • 8 views
  • 24 Feb, 2022
  • 1 location
Topical Vancomycin Over Sternal Edge in Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 0 views
  • 12 Sep, 2021
  • 1 location
Beta-Lactam InfusioN Group Study

The purpose of this study is to find out whether continuous infusion of beta-lactam antibiotics or intermittent infusion or beta-lactam antibiotics, offers more health advantages to patients or

antibiotic therapy
mechanical ventilation
meropenem
vasoconstrictors
septic shock
  • 214 views
  • 06 Oct, 2021
  • 108 locations
PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN)

comparing treatment with combination beta-lactam-beta-lactamase inhibitor and carbapenems. The investigators aim to evaluate the effect of definitive treatment with meropenem vs. piperacillin-tazobactam on

bacteremia
lactam
blood culture
meropenem
ceftazidime
  • 23 views
  • 28 Oct, 2021
  • 2 locations
BL Infusion Trial: Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia

The study plans to randomize a total of 240 patients infected with Gram-negative bacterial pneumonia to receive beta-lactam (meropenem, cefepime, or piperacillin/tazobactam) continuous or

respiratory failure
mechanical ventilation
assisted ventilation
chest radiograph
beta-lactam
  • 0 views
  • 13 Mar, 2022
  • 1 location
Pharmacokinetic Study of Vancomycin, Clindamycin and/or Gentamicin Administration During Surgery Using a Microdialysis Procedure

infections. The beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection

antibiotic therapy
vancomycin
clindamycin
antibiotics
gentamicin
  • 0 views
  • 09 Feb, 2022
  • 1 location
Addition of Probenecid to Penicillin-V Therapy (ADDPROPEN)

a larger number of beta-lactam antibiotics. Hypothesis: Addition of probenecid to oral phenoxymethylpenicillin (penicillin-V) has a clinically relevant effect on pharmacokinetic

Accepts healthy volunteers
  • 0 views
  • 03 May, 2022
  • 1 location
Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)

to examine the effects of two commonly used antibiotics (the beta-lactam, amoxicillin and the macrolide azithromycin) on human microbial populations and on metabolic and immune physiology, studying

Accepts healthy volunteers
  • 0 views
  • 23 May, 2022
  • 1 location