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Found 96 clinical trials
Efficacy and Safety Evaluation of PC-SOD for Injection in Reducing Myocardial Reperfusion Injury

The current study aims to evaluate different doses of PC-SOD injections for efficacy and safety in comparison to placebo, in order to provide a basis for future clinical trials in terms of experimental design and dose selection.

  • 0 views
  • 23 Jan, 2021
  • 2 locations
The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery

The purpose of this study is to determine if preforming a posterior left pericardiotomy prevents atrial fibrillation after cardiac surgery.

heart surgery
  • 14 views
  • 27 Jan, 2021
  • 1 location
Rate Control in Atrial Fibrillation II

The RATAF II study is a randomized, prospective, parallel group study, designed to compare the effects of two different drug regimens for rate control in permanent AF (atrial fibrillation). We will investigate on the difference in effects on exercise capacity, biomarkers (NT-proBNP (N-terminal pro-brain natriuretic peptide), troponins, hs-CRP), heart rate, …

beta blockers
fibrillation
nt-probnp
beta-adrenergic blocking agents
calcium
  • 16 views
  • 27 Jan, 2021
  • 1 location
Landiolol for Rate Control in Decompensated Heart Failure Due to Atrial Fibrillation

The study will include patients with acute heart failure with reduced left ventricular ejection fraction (<40%) triggered by atrial fibrillation (AF) with a heart rate of >130/min. Patients in cardiogenic shock, critical state, or patients requiring emergent electric cardioversion during the first 2 hours will be excluded. The patients will …

  • 0 views
  • 29 Jan, 2021
  • 1 location
Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices

Randomized comparison within the endoscopic esophageal varices ligation versus non-selective beta-blocker in the primary prevention of esophageal variceal bleeding in patients with HCC.

  • 0 views
  • 24 Jan, 2021
  • 1 location
Volatile Anesthetics in Cardiac Protection

Patients undergoing stenting procedures, or cardiac or non-cardiac surgery could develop myocardial damage as testified by cardiac troponin release. Sevoflurane (volatile anesthetic), routinely used in cardiac and non-cardiac anesthesia, has cardioprotective properties that could be useful to reduce cardiac damage, as indicated by cardiac troponin release in different contexts: stenting …

intravenous anesthesia
cardiac operation
sevoflurane
  • 19 views
  • 28 Jan, 2021
  • 2 locations
Exogenous Ketones for Acutely Decompensated HEart Failure

This study will evaluate whether supplementation of exogenous ketones in patients with severe left ventricular dysfunction and acutely decompensated heart failure requiring inotropic therapy would improve the patient's hemodynamics and symptoms.

  • 0 views
  • 29 Jan, 2021
  • 1 location
Effects of Ketones and Niacin in Heart Failure Patients

Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction. The mechanisms behind these marked hemodynamic effects are currently unknown, but could involve prostaglandin-release. 3-OHB is the endogenous ligand for the G protein-coupled receptor hydroxy-carboxylic acid 2 (HCA2) receptor. This receptor …

  • 0 views
  • 03 Mar, 2021
  • 1 location
Use of the Neovasc Coronary Sinus Reducer System for the Treatment of Refractory Angina Pectoris in Patients With Ngina Class 3-4 Who Are Not Candidates for Revascularization

The purpose of this study is to implant the Reducer in patients with the symptoms of refractory angina, that suffer from refractory angina who demonstrate reversible ischemia.

  • 106 views
  • 25 Jan, 2021
  • 2 locations
Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the …

  • 0 views
  • 22 Jan, 2021