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Found 95 clinical trials
Can a Modified Fat Diet With Low Glycaemic Load Improve Insulin Sensitivity and Inflammatory Mediators in Overweight People With Chronic Heart Failure?

This study is looking at overweight patients with chronic heart failure (CHF), to compare the effects of a modified fat diet with a reduced glycaemic load (diet 1); and a conventional low fat, high carbohydrate diet (diet 2) on: - insulin sensitivity (using the homeostasis model assessment [HOMA] model) - …

chronic heart failure
  • 16 views
  • 07 Nov, 2020
  • 1 location
Intracoronary Infusion of Mononuclear Cells Autologous Bone Marrow in Patients With Chronic Coronary Occlusion and Ventricular Dysfunction Previously Revascularized.

Clinical trial phase III, prospective, controlled, randomized, open. We hypothesize work that patients with chronic coronary occlusion and poor myocardial viability who failed to recover ventricular function after subjecting coronary revascularization with new techniques of recanalization, could achieve an improvement of ventricular function if given further regenerative treatment with mononuclear …

  • 33 views
  • 23 Jan, 2021
  • 3 locations
Dual Energy CT as a Noninvasive Method to Screen for Gastroesophageal Varices

Cirrhosis leads to portal hypertension and development of gastroesophageal varices, which are the most common cause for bleeding in cirrhosis and a major cause of death. The American Association for the Study of Liver Disease (AASLD) recommends screening endoscopy every 2 years to evaluate for gastroesophageal varices, and annual surveillance …

  • 0 views
  • 25 Jan, 2021
  • 1 location
CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone

The aim of this study is to determine if therapy with the aldosterone antagonist, Eplerenone, is associated with improved remodeling of the left ventricle in patients with cardiomyopathy. We will determine if any benefit to cardiac remodeling is associated with improved clinical outcomes, including improved exercise capacity and reduced incidence …

fibrosis
aldosterone antagonists
  • 12 views
  • 07 Nov, 2020
  • 1 location
Does Propranolol a Beta Blocker Attenuate Stress-Induced Drinking?

For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol extended release (160mg/day or placebo; n=10 per cell) to evaluate whether …

  • 11 views
  • 29 Jan, 2021
  • 1 location
Comparison of Coronary CT Angiography to Invasive Coronary Angiography

The purpose of the trial is to investigate the accuracy of coronary CT compared to the conventional "gold standard" cardiac catheterization.

angiography
coronary ct
computed tomography angiography
  • 4 views
  • 07 Nov, 2020
  • 1 location
Tailoring Pacemaker Output to Physiology in Chronic Heart Failure

Aims: To explore the clinical effect on exercise tolerance and quality of life, safety and tolerability of pacing at higher outputs in patients with chronic heart failure and a pacemaker. Background: Heart failure (HF) is a very common condition of breathlessness or fatigue associated with heart muscle weakness. In around …

left ventricular systolic dysfunction
cardiac resynchronization therapy
exercise test
weakness
dyspnea
  • 0 views
  • 24 Jan, 2021
  • 1 location
Beta-blockers for Oesophageal Varices

To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices

  • 0 views
  • 24 Jan, 2021
  • 3 locations
Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease

Background: In patients with chronic obstructive pulmonary disease (COPD) and concomitant cardiovascular conditions cardio-selective beta-blockers reduce mortality and can be used without

spirometry
asthma
pulmonary function test
bronchodilator
copd exacerbation
  • 21 views
  • 26 Jan, 2021
  • 3 locations
TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"

REBOOT clinical trial will study whether long-term maintenance beta-blockers therapy results in a clinical benefit after heart attack without reduced left ventricular function. Half of the

angiography
myocardial infarction
infarct
beta blockers
heart failure
  • 30 views
  • 05 Feb, 2021
  • 148 locations