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Found 30 clinical trials
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Severe Uncontrolled Asthma

Severe Uncontrolled Asthma

  • 1092 views
  • 08 Nov, 2020
  • 1 location
A Study of Benralizumab in Patients With Eosinophilic Esophagitis

The aim of this Phase 3 study is to investigate the use of benralizumab as a treatment for patients with EoE. The effect of doses of benralizumab on EoE histologic signs and symptoms will be

  • 0 views
  • 17 Feb, 2021
  • 73 locations
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg

nasal abnormality
eosinophilia
corticosteroid therapy
cyclophosphamide
oral prednisolone
  • 20 views
  • 15 Feb, 2021
  • 75 locations
A Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)

This is a multicentre, randomised, double-blind (DB), parallel-group, placebo-controlled, 24-week Phase 3 study to compare the efficacy and safety of benralizumab versus placebo administered by

  • 0 views
  • 13 Feb, 2021
  • 42 locations
Effect of Benralizumab in Patients With Severe Nasal Polyps

This is a randomized placebo controlled trial to evaluate the effect of benralizumab on people with severe nasal polyps.

  • 3 views
  • 08 Nov, 2020
  • 1 location
Benralizumab in Patients With Inadequate Response to Anti-IL5 Monoclonal Antibody Therapies

In severe prednisone-dependent eosinophilic asthma, Benralizumab would suppress airway eosinophilia that is not suppressed by either Mepolizumab or Reslizumab and this would be associated with

  • 22 views
  • 28 Jan, 2021
  • 1 location
PK/PD and Long Term Safety Study of Benralizumab in Children With Severe Eosinophilic Asthma

This study will evaluate the PK, PD and long-term safety of Benralizumab administered subcutaneously in 30 children aged 6 to 11 years with severe eosinophilic asthma. Up to an additional 3

  • 1 views
  • 25 Feb, 2021
  • 18 locations
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment

airway remodelling
benralizumab
fluticasone
corticosteroids
pulmonary function test
  • 119 views
  • 17 Feb, 2021
  • 46 locations
Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)

This is a randomized, double-blind, placebo-controlled, parallel-group, international, multicenter, Phase 3 study to evaluate the efficacy and safety of repeat dosing of benralizumab 30 mg

rhinosinusitis
corticosteroids
polyposis
aspirin
eosinophil count
  • 20 views
  • 24 Jan, 2021
  • 35 locations
Efficacy and Safety Study of the Use of Benralizumab for Patients With Moderate to Severe Atopic Dermatitis

The purpose of the study is to compare the efficacy and safety of benralizumab versus placebo and to compare benralizumab dosing regimens during extension period.

  • 0 views
  • 18 Feb, 2021
  • 44 locations