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Found 18 clinical trials
Efficacy and Safety of Belimumab in Neuromyelitis Optica Spectrum Disorders

Neuromyelitis Optica Spectrum Disorders (NMOSD) is associated with a pathological humoral immune response against the aquaporin-4(AQP-4) water channel. Belimumab (Benlysta ®) is a human

Accepts healthy volunteers
  • 0 views
  • 28 May, 2022
  • 1 location
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety of the study. Belimumab will be administered

raynaud's syndrome
mycophenolate
rituximab
arthritis
immunosuppressive agents
  • 29 views
  • 07 Oct, 2022
  • 1 location
Efficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous Nephropathy (ITN080AI) (REBOOT)

The primary objective of this study is to evaluate the effectiveness of belimumab and intravenous rituximab co-administration at inducing a complete remission (CR) compared to rituximab alone in

proteinuria
arthritis
glomerular filtration rate
remission
systemic lupus erythematosus
  • 340 views
  • 13 Oct, 2022
  • 11 locations
Efficacy and Immunological Evaluation of Belimumab Plus Low Dose IL-2 in the Treatment of Systemic Lupus Erythematosus

The purpose of this study was to explore the clinical and immunological efficacy of belimumab plus low dose IL-2 in systemic lupus erythematosus.

interleukin-2
cyclosporine
antimalarials
hydroxychloroquine
lupus
  • 0 views
  • 05 Apr, 2022
  • 1 location
A Multi-Center, Open-Label Study to Evaluate Safety, Efficacy and Pharmacokinetics of Belimumab Plus Standard Therapy in Chinese Paediatric Patients With Active Systemic Lupus Erythematosus (SLE)

This study will be conducted to evaluate the safety, efficacy and pharmacokinetics of belimumab administered in combination with background standard therapy in pediatric participants with active

  • 0 views
  • 12 Oct, 2022
  • 9 locations
Precision Medicine in LN: A Multicenter Proof-of-concept Study for Histopathological Biomarkers Analysis in Renal Biopsy

, they recommend as an alternative the use of rituximab (RTX) 1000 mg IV repeated after 15 days. Belimumab has been shown to be significantly more effective than placebo in the treatment of

glucocorticoids
treatment regimen
cyclophosphamide
mycophenolate
proteinuria
  • 0 views
  • 11 May, 2022
  • 1 location
PRediction Of Flares In Lupus With autoantibodiEs and Chemokines (PROFILE)

Rationale: Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease with a wide range of clinical manifestations affecting several organs. Although the management of lupus patients has improved in the last years, accurate models for predicting disease progression are lacking. Objective: To prospectively evaluate the predictive value of a …

lupus
  • 0 views
  • 03 Jun, 2022
  • 1 location
EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) (NISSC-2)

The aim of the study is to assess the effectiveness of various post-transplant treatment management approaches on clinical and immune biological responses after Autologous Hematopoietic Stem Cell transplantation (AHSCT) for Systemic Sclerosis (SSc) as currently performed by the different treatment protocols used in routine clinical practice across Europe in various …

progressive systemic sclerosis
treatment regimen
  • 0 views
  • 26 Feb, 2022