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Found 24 clinical trials
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation (CHOMP)

The primary objective is to assess the activity and efficacy of pembrolizumab, a checkpoint inhibitor, in Veterans with metastatic castration-resistant prostate cancer (mCRPC) characterized by either mismatch repair deficiency (dMMR) or biallelic inactivation of CDK12 (CDK12-/-). The secondary objectives involve determining the frequency with which dMMR and CDK12-/- occur in …

  • 18 Feb, 2022
  • 8 locations
Safety and Cost-efficiëncy of New Imaging Techniques in Patients Suspected of Coronary Artery Disease (iCORONARY)

Yearly, 180 000 patients in the Netherlands are referred to a cardiologist with symptoms suspected of coronary artery disease (CAD). To assess this, multiple diagnostic tests are available. Non-invasive imaging tests, such as coronary CT-scan, are safe, relatively cheap and can effectively rule-out CAD. However, when CAD is present, coronary …

angina pectoris
coronary ct
  • 05 Jun, 2022
  • 1 location
Checklist-guided Shared Decision-making for Code Status Discussions in Medical Inpatients.

This cluster-randomized, multicenter trial is designed to investigate the effect of checklist-guided shared decision-making including decision aids and communication of expected outcome on patients' decision regarding their code status, and at the same time, if it improves decision-making quality as judged by patient's decisional comfort, patient knowledge and involvement in …

Accepts healthy volunteers
  • 30 May, 2022
  • 1 location
Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections (TRACE)

Haematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality. Adoptive transfer of virus-specific T cells is an attractive approach to restore protective T-cell immunity in patients with refractory viral infections after allogeneic HSCT. …

  • 15 Mar, 2022
  • 13 locations
A Study to Assess Vamorolone in Becker Muscular Dystrophy (BMD)

This Phase II pilot study is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, PD, and exploratory clinical efficacy of vamorolone 500mg (250mg for body weight <50 kg) daily administered orally compared to placebo over a treatment period of 24 weeks in males with BMD. Funding Source …

respiratory assessment
becker muscular dystrophy
dmd gene
drug test
  • 07 Oct, 2022
  • 1 location
  • 20 Oct, 2022
  • 6 locations
Dynamics of 18-FDG Uptake in Stage III/IV Non Small Cell Lung Cancer During First Line Pembrolizumab Treatment (iTEP1)

The aim of this study is to describe the early dynamics of 18-FDG uptake in non smal cell lung cancer during first line treatment with pembrolizumab, and to evaluate whether or not they differ according to treatment response at 3 months.

lung carcinoma
  • 19 Feb, 2022
  • 2 locations
Umbilical Cord Blood Transplantation From Unrelated Donors

This study is a single-center, treatment protocol with 4 possible preparative regimens, designed to validate the process of umbilical cord blood stem cell transplantation at our institution.

severe combined immunodeficiency
cell transplantation
umbilical cord blood transplantation
shortening fraction
  • 12 Jul, 2022
  • 1 location
Schulze Muscular Dystrophy Ability Clinical Study

The primary objective of the Schulze study is to evaluate the function of the upper limbs of subjects diagnosed with neuromuscular disorders, with and without use of the Abilitech Assist device in the clinic and home environments. Functional outcomes will include documenting active range of motion and the ability to …

range of motion
muscular dystrophy
  • 24 Oct, 2022
  • 1 location
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning: a Phase II Randomized Study From the Belgian Hematology Society (BHS) (HLA)

The present project aims at comparing two conditioning regimens (FM-PTCy vs FM-ATG). The hypothesis is that one or the two regimens will lead to a 2-year cGRFS rate improvement from 30% (the cGRFS rate with FM without ATG/PTCy) to 45% (Pick-a-winner phase 2 randomized study).

cell transplantation
hematologic malignancy
myelodysplastic syndromes
  • 28 Oct, 2022
  • 9 locations