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Found 101 clinical trials
Pulsed Low Dose Rate Radiation With Concurrent Chemotherapy for Non-Small Cell Lung Cancer and Esophageal Cancer

is high (approximately 20%) when conventional external beam radiation is utilized. Severe acute esophagitis can cause many adverse consequences such as severe discomfort, weight loss, hospitalization

esophagus cancer
absolute neutrophil count
total bilirubin
  • 08 Mar, 2022
  • 1 location
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA

exhibits the most aggressive behavior, resulting in median overall survival durations of only 9-12 months for GBM, and 3-4 years for AA. Initial therapy consists of either surgical resection, external beam

mixed oligoastrocytoma
karnofsky performance status
astrocytoma, anaplastic
intraarterial cerebral infusion
malignant glioma
  • 05 Nov, 2021
  • 1 location
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor

The researchers are doing this study to find out if there are differences in the resting state brain networks of children and young adults (ages 6-21) after treatment with proton beam radiation

Accepts healthy volunteers
  • 12 Jul, 2022
  • 1 location
Stereotactic Hypofractionated Accelerated Radiotherapy Post-Prostatectomy (SHARP)

The present phase I trial evaluates the feasibility of a postoperative stereotactic hypofractionated external beam radiation therapy delivered in patients who underwent radical prostatectomy

stereotactic body radiation therapy
androgen suppression
external beam radiation therapy
  • 25 Feb, 2022
  • 1 location
MRI for Assessing Prostate Cancer Response (NA_00067284)

Prostate cancer is one of most common cancers in America, affecting 1 in 6 men. External beam radiation therapy is one of the common methods to treat prostate cancer. Although radiotherapy is

external beam radiation therapy
  • 06 Jun, 2022
  • 1 location
SBRT vs. Conventional Fractionation With HDR Boost for Prostate Cancer (SHARP)

Random assignment between SBRT and conventionally fractionated boost following HDR brachytherapy for prostate cancer.

  • 10 May, 2022
  • 1 location
A Randomized Phase II Trial Evaluating High Dose Rate Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer

The purpose of this study is to evaluate the dose of High Dose Rate (HDR) brachytherapy chosen for this study as well as a commonly used alternate form of brachytherapy called low dose rate (or seed) brachytherapy. Investigators would like to understand how these treatments control the prostate cancer and …

transrectal ultrasound
bone scan
ct scan
adenocarcinoma of prostate
  • 21 Sep, 2022
  • 7 locations
Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

This phase II trial studies the side effects and how well pembrolizumab works in combination with standard therapy in treating patients with glioblastoma. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow …

serum pregnancy test
blood transfusion
platelet count
  • 25 Apr, 2022
  • 1 location
A Phase I Clinical Trial of Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

brain tumor
therapeutic agent
glioblastoma multiforme
platelet count
  • 18 Sep, 2022
  • 1 location
Intra-operative Radiotherapy For Breast Cancer Women After NSM

The role of NSM is still controversial, mainly because of concern about the oncologic safety of the nipple-areola complex (NAC).INTRABEAM (Carl Zeiss, Oberkochen, Germany) is the most widely used mobile intraoperative radiotherapy (IORT) device to date. This study aims to assess the value of the INTRABEAM system for breast cancer.

breast-conserving surgery
breast cancer
ductal carcinoma in situ
  • 21 Jan, 2021