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Found 31020 clinical trials
Featured trial
Study to evaluate TEPEZZA® in patients with Chronic (Inactive) Thyroid Eye Disease (TED)

not meet the desired response after the 24-week treatment period may receive up to 8 additional infusions of TEPEZZA®.  After completion of the treatment period, there will be a follow up phone

  • 13 views
  • 13 Oct, 2022
  • 9 locations
Featured trial
Study of INCA 0186 in Subjects With Advanced Solid Tumors

(SCCHN) and specified gastrointestinal (GI) malignancies have been selected as indications of interest for this study. Participants with CD8 T-cell-positive tumors will be selected as these tumors are

  • 8 views
  • 07 Oct, 2022
  • 9 locations
Featured trial
A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (LIGHTHOUSE)

symptoms. Researchers will also learn more about the safety of BIIB122. A description of how the study will be done is given below. Participants will take BIIB122

hoehn and yahr scale
depression
movement disorder
motor symptoms
  • 1 views
  • 16 Nov, 2022
  • 2 locations
Featured trial
A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia

dementia (PwD) compared to the control group. A total of 64 family caregivers of PwD who meet the inclusion criteria will be recruited and randomized to either the intervention group or the control group

depression
  • 31 views
  • 28 Oct, 2022
  • 1 location
Featured trial
Study in Parkinson Disease of Exercise (SPARX3)

-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The

datscan
SPECT Scan
movement disorder
  • 169 views
  • 07 Oct, 2022
  • 26 locations
Featured trial
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)  

, double blind, placebo controlled part, preceded by a screening period of up to 4 weeks before Day 1. On Day 1 of Part A, participants will be randomized in a 2:1 ratio to the SAR443820 treatment

edaravone
riluzole
body mass index
primary lateral sclerosis
  • 40 views
  • 27 Jan, 2023
  • 18 locations
Featured trial
Social-Life Enhancing Activities for Caregivers

Social LEAF to control (30 caregivers in each arm) on loneliness (primary outcome), positive affect (mechanism), and social engagement (mechanism). Data will also be collected on acceptability and

Accepts healthy volunteers
dementia
  • 0 views
  • 15 Sep, 2022
  • 1 location
Featured trial
SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients (CARMEN-LC03)  

Primary Objectives: Study is designed with two primary endpoints that will be analyzed on randomized participants at the time of the cut-off date for each given analysis

  • 180 views
  • 27 Jan, 2023
  • 5 locations
Featured trial
Cognitive Fitness for Depression in Older Adults

This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance …

  • 85 views
  • 22 Jan, 2022
  • 1 location
Featured trial
Methodology Issues in a Tailored Light Treatment for Persons With Dementia

Tailored light treatment will increase sleep efficiency, reduce depression and reduce agitation scores in those with Alzheimer's disease and related dementia

mini-mental state examination
agitation
mental state examination
depression
Accepts healthy volunteers
  • 6 views
  • 01 Apr, 2022
  • 2 locations