Found 31091 clinical trials
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)
Primary Objective: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis (PPMS) Secondary Objectives: To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality of life To evaluate safety …
- 113 views
- 20 Jan, 2023
- 11 locations
A Phase 2, Open-Label, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement
at 13.5 mg on a 2-week-on–therapy and 1-week-off–therapy schedule. With Protocol Amendment 3, the administration schedule will be adjusted, and newly enrolled subjects will
- 182 views
- 19 Dec, 2022
- 35 locations
A Phase 4, Randomized, Open-label, Multicenter Efficacy and Safety Study of Standard Dose of Radium-223 Dichloride vs. Standard Doses of Novel Anti-hormonal Therapy (NAH) in Patients With Bone Dominant Metastatic Castration Resistant Prostate Cancer (mCRPC) Progressing on/After One Line of NAH
;The NAH drugs used in this study will be either abiraterone acetate (Zytiga) (plus prednisone/prednisolone) or enzalutamide (Xtandi). Both of them are standard approved
- 24 views
- 08 Feb, 2022
- 20 locations
C3991004 -T2DM
their blood sugar in good control. Individuals diagnosed with diabetes that are on metformin or individuals with obesity without diabetes will be included in the study.Those participating in
- 186 views
- 25 Jan, 2023
- 29 locations
The Orchestra Study: An 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease
participant. Participants will be randomly assigned (like drawing straws) to receive either the study drug or placebo; they will have an equal chance (50%) of receiving either the study drug or a placebo
- 0 views
- 25 Jan, 2023
- 42 locations
Gemini Trial
We are currently recruiting patients with Generalized Pustular Psoriasis (GPP) for a study that investigates the effectiveness and safety of the drug imsidolimab.
- 23 views
- 10 Mar, 2022
- 17 locations
Ulcerative Colitis Research Study
Local doctors are looking for people with Ulcerative Colitis for clinical research studies of an investigational medication. Must be receiving treatment for Ulcerative Colitis
- 954 views
- 07 Nov, 2020
- 1 location
Dose Ranging Study of Amlitelimab in Adult Participants With Moderate-to-severe Asthma (TIDE-asthma)
) will be up to approximately 76 weeks for participants not going into LTS study and will be up to approximately 64 weeks for participants going into LTS study. The randomized treatment
- 18 views
- 24 Jan, 2023
- 5 locations
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children With Atopic Dermatitis (TRuE-AD3)
will be randomized 2:2:1 to blinded treatment with ruxolitinib cream 0.75% ,1.5% , or vehicle cream, with stratification by baseline IGA score and age. At Week 8, efficacy will be evaluated
- 53 views
- 07 Oct, 2022
- 52 locations
Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis
with moderate to severe UC. Dose selection for further clinical development will be based on the multiple efficacy, safety and PK parameters. The study consists of 4 parallel arms (3 dose groups
- 21 views
- 24 Jan, 2023
- 2 locations