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Found 35126 clinical trials
Featured trial
A trial evaluating Pegloticase administered with a shorter infusion duration in patients with Uncontrolled Gout receiving methotrexate.

The purpose of this study is to assess the safety, tolerability and efficicacy of pegloticase administered with a shorter infusion duration in participants with uncontrolled gout receiving methotrexate.

  • 08 Jun, 2022
  • 12 locations
Featured trial
Assessment of Safety, Tolerability, and Efficacy Measured by Amyloid Reduction of LY3372993 in Early Symptomatic Alzheimer's Disease

The reason for this study is to collect safety and efficacy information regarding the study drug remternetug in participants with early Alzheimer's disease (AD).

mini-mental state examination
  • 24 Oct, 2022
  • 74 locations
Featured trial
A Randomized Double-blind Placebo-controlled Parallel Group Study Assessing the Efficacy and Safety of Dupilumab in Patients With Allergic Fungal Rhinosinusitis (AFRS)  

Primary Objective: To evaluate the ability of dupilumab to reduce the need for rescue therapy with systemic corticosteroids (SCS) or surgery of AFRS in patients with AFRS who previously have had sino-nasal surgery Secondary Objectives: To evaluate the efficacy of treatment with dupilumab to reduce sinus opacification in a population …

  • 01 Dec, 2022
  • 5 locations
Featured trial
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-design Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

This study will be conducted to evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in participants with dementia of the Alzheimer's

  • 15 Oct, 2022
  • 82 locations
Featured trial
An Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204) (POD1UM-204)

platinum-based chemotherapy. retifanlimab will be administered as monotherapy or in combination with other immunotherapy or targeted agents.

metastatic endometrial cancer
platinum-based chemotherapy
  • 25 Oct, 2022
  • 53 locations
Featured trial
A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80 (LUMA)

up to a minimum of 48 weeks and a maximum of 144 weeks. Certain medications for PD will be allowed at enrollment for a subset of participants. The majority of clinic visits will be

movement disorder
hoehn and yahr scale
  • 17 Nov, 2022
  • 6 locations
Featured trial
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)

cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate

positron emission tomography
mini-mental state examination
mild dementia
  • 22 Sep, 2022
  • 46 locations
Featured trial
An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects

daily. It has been well tolerated in earlier studies and may be a convenient option for Alzheimer’s patients and their families. To learn more about the clinical research study and to see if you may

apolipoprotein e
mild dementia
mini-mental state examination
  • 20 Sep, 2022
  • 79 locations
Featured trial
Study to evaluate HZN-825 in patients with Diffuse Cutaneous Systemic Sclerosis (dcSSc)

(administered once daily (QD) or twice daily (BID)), or a placebo regimen for 52 weeks.Participants who complete all study visits may be eligible to enter a 52-week extension study where

raynaud's syndrome
raynaud's phenomenon
diffuse cutaneous systemic sclerosis
  • 22 Oct, 2022
  • 85 locations
Featured trial
Preventing Alzheimer's With Cognitive Training (PACT)

years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across

Accepts healthy volunteers
cognitive stimulation
mild cognitive impairment
cognitive impairment
  • 28 Oct, 2022
  • 5 locations