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Found 16 clinical trials
Efficacy and Safety of Tozorakimab (MEDI3506) in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)

The purpose of this Phase III study is to evaluate the efficacy and safety of Tozorakimab (MEDI3506) Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants …

  • 18 Jun, 2022
  • 45 locations
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS) (KALOS)

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care

  • 19 Jun, 2022
  • 240 locations
Medico-economics and QoL of Obese Patients Followed by Medical Analysis Laboratories (BIOSAOS ) (BIOSAOS)

Obesity is a major risk factor for obstructive sleep apnea (OSA). However, OSA is still largely under diagnosed in patients with a high cardiovascular risk. In this population the STOP-BANG

blood bicarbonate
respiratory disorder
respiratory disease
  • 19 Feb, 2022
  • 1 location
The Role of the Device Operating Under the Continuous Positive Airway Pressure in the Recovery Process of Cochlea

healthy individuals (n32). Research plan: All participating in this study will complete the following questionnaires: STOP- BANG and Epworth drowsiness scale. Subjects of the target group with

Accepts healthy volunteers
  • 11 May, 2022
Value of Screening and Treatment of SAHS in the Management of AF Ablation Candidates (SLEEP-AF)

The present prospective cohort study (not randomized) analyses the value of screening and treatment of SAHS in the management of patients with AF refractory to antiarrhythmics drugs, potentially candidates for ablation. Patients at low risk of suffering from SAHS will follow conventional management of their AF, according to the usual …

hypopnea syndrome
  • 23 Mar, 2022
  • 1 location
Effectiveness of Dry Needling in Chronic Neck Pain.

Objectives: To investigate the effect of combining real or placebo dry needling with therapeutic exercise in self-reported pain, pressure pain sensitivity, neck disability, global rating of change (GROC) scale, muscle viscoelastic properties (muscle tone and stiffness) and left/right discrimination ability in adults with chronic non-specific neck pain. Design: Quantitative, experimental, …

neck exercises
sham treatment
dry needling
  • 24 Apr, 2022
  • 1 location
Back in the Game: a Smartphone Application to Support Athletes Returning to Sport After Serious Injury (BANG)

Returning to sport is one of the primary concerns of athletes following injury. Yet, after serious injury, up to 50% of athletes do not return to competitive sport. Psychological factors play an important role in the athlete's return to sport after anterior cruciate ligament (ACL) reconstruction, and physical and psychological …

ligament reconstruction
anterior cruciate ligament tear
cruciate ligament rupture
rehabilitation program
  • 09 Feb, 2022
  • 7 locations
Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA

Lung protective ventilation (LPV) has been proposed to reduce the incidence of postoperative pulmonary complications (PPCs), and protect against ventilator induced lung injury (VILI).

lung injury
pulmonary complications
  • 22 Mar, 2022
  • 1 location
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which we believe is detrimental to MS. We will examine clinical data (MRI, lab results, medical history, labs, and sleep studies) of Dr. Sloane's MS patients. …

  • 26 Jan, 2021
Same-Day Antiretroviral Therapy Initiation

Data from a total of 2,500 walk-in or referred individuals who have been confirmed (diagnosed) HIV positive and accessing care and treatment services at the hospitals targeted by this study will be examined. The starting period for this project is estimated to be the last quarter (Q4) of fiscal year …

antiretroviral therapy
HIV Vaccine
antiretroviral agents
  • 13 Feb, 2022
  • 11 locations