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Found 11 clinical trials
Early Diagnosis of Native and Device-associated Meningitis

Device-associated meningitis is a severe complication after implantation of various central nervous system (CNS) devices such as ventriculoperitoneal (VP) and ventriculoatrial (VA) shunts, external ventricular drains (EVD), lumbar drains (ELD) and intrathecal pumps. In contrast to native meningitis, these infections are hard to diagnose both clinically and on the laboratory …

antibiotics
  • 0 views
  • 14 Dec, 2021
  • 2 locations
Meningococcal Serogroup ACYWX Conjugate Vaccine in Comparison With MenACWY-TT Conjugate Vaccine

Infants aged 9 months will be randomized to receive a meningococcal vaccine at 9 months or 15 months. Infants randomized to the 9-month age group will be further randomized in a 2:1 ratio to receive a single dose of the experimental meningococcal vaccine (NmCV-5) or a single dose of the …

Accepts healthy volunteers
  • 0 views
  • 21 Apr, 2022
A Controlled Human Pneumococcal Infection Model (PIM) Study (PIM)

Infection with Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia, bacterial meningitis and bacteraemia worldwide in the very young and the elderly. Although

Accepts healthy volunteers
antibiotics
meningitis
vaccination
pneumonia
  • 0 views
  • 17 Jun, 2022
  • 1 location
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis (TBMBIOMARKER)

The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests. TB meningitis (TBM), an extrapulmonary form of TB, is the most severe manifestation of paediatric TB. TBM results in high morbidity and mortality in children, despite the availability of chemotherapy, …

  • 0 views
  • 03 Jun, 2022
  • 1 location
Neonatal Bacterial Meningitis Cohort

Neonatal bacterial meningitis (BM) is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality

bacterial meningitis
Accepts healthy volunteers
  • 19 views
  • 03 Mar, 2022
  • 1 location
National Bacterial Meningitis Study

Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data. The epidemiology of

  • 0 views
  • 31 Mar, 2021
  • 1 location
Validation of a Predictive Rule for the Diagnosis of Viral Meningitis in Adult Emergency Departments (Adult-BMS)

> Viral meningitis is the most common, with enterovirus meningitis having a classically excellent prognosis. Bacterial meningitis is less frequent but more serious.The current public health objective is

bacterial meningitis
antibiotics
  • 0 views
  • 24 Mar, 2022
  • 1 location
Fosfomycin i.v. for Treatment of Severely Infected Patients (FORTRESS)

intravenously administered fosfomycin, including patients with osteomyelitis, complicated urinary tract infection, nosocomial lower respiratory tract infection, bacterial meningitis/central nervous system

lower respiratory tract infection
bacterial infections
bacteremia
osteomyelitis
bacterial meningitis
  • 644 views
  • 27 Jan, 2022
  • 23 locations
Linearity and Non-linearity of Cerebral Autoregulation

hemorrhage or bacterial Meningitis. Up to now, there is lack of a simple and easy to perform bed side test that would allow for to intervene when CA failure is indicated. For this purpose, we explore the

  • 0 views
  • 26 Jan, 2021
  • 1 location
Central Nervous System Infections in Denmark (DASGIB)

The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervous system (CNS) infections by a prospective registration of clinical characteristics and outcome of all adult (>17 years of age) patients …

neurologic finding
antigen tests
antibiotics
headache
blood culture
  • 345 views
  • 26 Feb, 2022
  • 8 locations