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Found 63 clinical trials
Blue Light Therapy in Reducing Inflammation During Sepsis

Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome. The ability to modify the host response to the stress of major operations and sepsis carries immense potential to improve patient care. This study …

white blood cell count
a 12
critical illness
colon resection
  • 10 Mar, 2022
  • 1 location
Functional Non Specific Immunity Monitoring After Kidney Transplantation Using an Interferon Gamma Test

The best renal replacement therapy is kidney transplantation. It improves end-stage renal kidney disease (ESRD) patients quality of life and increases their survival, but still remains risky. Morbidity in kidney transplantation is dominated by two main complications : acute graft rejection and infections. To maintain an accurate balance between rejection …

  • 22 Jan, 2021
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia (ACCESS)

Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens. Retrospective analysis of observational clinical studies in CAP showed that the addition of macrolides to standard antibiotic therapy conferred a significant survival benefit. The proposed benefit of macrolides is coming …

antibiotic therapy
antimicrobial agent
  • 19 Apr, 2022
  • 7 locations
Personalized Immunotherapy in Sepsis

im of ImmunoSep is to assess whether personalized adjunctive immunotherapy directed against a state of either fulminant hyper-inflammation or immunoparalysis is able to change sepsis outcomes. Patients will be selected by a panel of biomarkers and laboratory findings and will be allocated to placebo or immunotherapy treatment according to their …

organ failure
  • 23 Aug, 2021
  • 17 locations
VENOUS: A Translational Study of Enterococcal Bacteremia

The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect …

  • 24 Jan, 2021
  • 8 locations
Increasing Insulin Resistance as a Predictor of Impending Bacteremia

in insulin resistance, as expressed in an increase in the patient's insulin intake, can predict the development of sepsis secondary to bacteremia in the intensive care unit.

  • 02 May, 2022
  • 1 location
Next Generation Pathogen Sequencing for Prediction of Adverse Events

documented infection is bloodstream infection (BSI), which can be associated with severe sepsis or death. Current methods of diagnosis require a significant load of live bacteria in the blood making early

  • 15 Jun, 2022
  • 1 location
Description of Lung Transplant Patients With Microbiologically Documented Stenotrophomonas Maltophilia Pneumonia and Impact of Treatment on Outcome (STENO_SOT)

mortality, particularly in immunocompromised patients. The mortality of infections (bacteremia, pneumonia) related to Stenotrophomonas maltophilia is variable and is estimated between 21 and 69

  • 12 Mar, 2022
  • 1 location
Prospective Evaluation of Complications of MidLine Catheters in the ICU (COMIDREA)

complications include deep vein thrombosis (DVT) and catheter-related bacteremia (CRB). There is very little data on the use of CMs in intensive care units (ICU). Resuscitation patients are more likely

  • 16 Jun, 2022
  • 1 location
Leptospirosis Registry Gathers Knowledge on Epidemiology, Clinical Course, Prognostic Factors and Molecular Characteristics for Invasive Leptospirosis Disease (Leptoscope)

Leptospirosis is a worldwide zoonotic diseases caused by pathogenic Leptospira spp. Human are accidental hosts, who acquired infections after exposition to animal urine, contaminated water or soil, infected tissue. Incidence of invasive leptospirosis disease causing acute kidney injury, acute respiratory distress syndrome (ARDS), myocarditis, hepatic dysfunction, hemorrhage and multi-organ failure, …

  • 07 Jun, 2022
  • 1 location