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Found 63 clinical trials
Acalabrutinib and Venetoclax Treatment of Newly Diagnosed Patients With CLL at High Risk of Infection or Early Treatment

Many patients with CLL have a weakened immune system due to their disease. It increases their risk of developing serious, treatment-requiring infections such as blood poisoning or pneumonia

acalabrutinib
neutrophil count
cancer
venetoclax
gilbert's syndrome
  • 9 views
  • 26 Feb, 2022
  • 3 locations
Vaccine Response in Patient With Sepsis (Vaccis)

treated for an infection (bacteremia, pneumonia, urinary tract infection, etc.). In order to respond to this problem, the investigators have chosen to evaluate the vaccine response to Prevenar 13 (PCV13

bacteremia
pneumococcal
pneumonia
  • 0 views
  • 01 May, 2022
  • 1 location
A Controlled Human Pneumococcal Infection Model (PIM) Study (PIM)

Infection with Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia, bacterial meningitis and bacteraemia worldwide in the very young and the elderly. Although

antibiotics
Accepts healthy volunteers
vaccination
meningitis
pneumonia
  • 0 views
  • 17 Jun, 2022
  • 1 location
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients (NIPA)

before it occurs. A preventive strategy could in turn reduce the occurrence of complications related to impaired gastrointestinal transit such as ventilator-acquired pneumonia, bacteremia etc. It could

mechanical ventilation
cancer
  • 0 views
  • 13 Apr, 2022
  • 3 locations
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients (TEMODELTA)

with temocillin for (i) complicated urinary tract infection and pyelonephritis (associated or not with bacteremia), or (ii) lower respiratory tract infection, or (iii) abdominal infection, and

bacteremia
antibiotics
abdominal infection
  • 0 views
  • 20 Jun, 2022
  • 1 location
Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock (DéPOH)

De-escalation aims at reducing the use of broad-spectrum antibiotics and therefore the emergence of multidrug-resistant (MDR) pathogens. Observational studies suggested that this strategy seems to be safe. However, there is no adequate, direct evidence showing de-escalation of antimicrobial agents to be effective and safe for onco-hematology patients with sepsis or …

treatment regimen
primary cancer
antibiotics
  • 1 views
  • 01 Feb, 2022
  • 1 location
Dysbiosis and Immune Reconstitution After Allo-HSCT

Preliminary (proof of concept), monocentric, interventional, prospective, non-randomized and analytic trial designed to simultaneously explore intestinal microbiota changes and early post-transplant immune reconstitution, and to correlate biological data with clinical data (antibiotics use, stress level, GVHD).

  • 0 views
  • 22 Jan, 2021
  • 1 location
Antibiotic Prophylaxis in Patients Undergoing GVO (ABX-GV)

We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.

antibiotics
liver disease
endoscopy
gastric varices
antibiotic therapy
  • 0 views
  • 16 Feb, 2022
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

Some tumors are difficult to treat with chemotherapy or radiation. One of the reasons is that areas of the tumor do not have many blood vessels, which makes it difficult for drugs to reach those areas. One way that researchers have recently tried to overcome this problem is by injecting …

serum total bilirubin
tumor cells
chemotherapy drugs
doxycycline
metastasis
  • 57 views
  • 18 May, 2022
  • 1 location
Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis

Background Chronic granulomatous disease (CGD) weakens the body's defense against germs. CGD can also damage the colon. It can cause inflammation (colitis) that disrupts the good bacteria. Placing good bacteria from donor stool into the intestine of a person with CGD (called fecal microbiota transplantation, or FMT) may help. Objective …

  • 0 views
  • 19 Jun, 2022
  • 1 location