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Found 61 clinical trials
Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)

-operative local and systemic infections. Burn surgery is associated with a high risk of bacteremia and postoperative infections and sepsis. However, antibiotic prophylaxis exposes to the risk of selecting

  • 0 views
  • 26 Jan, 2021
  • 1 location
Reduction of Pathogen Load From the Blood in Septic Patients With Suspected, Life-threatening Bloodstream Infection

Safety and Performance Evaluation of Seraph 100 Microbind Affinity Blood Filter (Seraph 100) in the reduction of pathogen load from the blood in septic patients with suspected, life-threatening bloodstream infection

Accepts healthy volunteers
  • 0 views
  • 23 Dec, 2021
  • 19 locations
Non-inferiority Trial Comparing Cloxacillin vs Cefazolin in Methicillin-susceptible Staphylococcus Aureus Bacteremia (CLOCEBA)

"Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia remains a major cause of community- or hospital-acquired bloodstream infections with an overall mortality estimated around 25

  • 9 views
  • 27 Feb, 2022
  • 1 location
A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremia

The objectives of this study is to exploratory whether vancomycin + delpazolid is more effective to the standard of treatment (vancomycin)/ for hospitalised adults with MRSA bacteraemia.

  • 0 views
  • 10 May, 2022
  • 1 location
Can the Relative Fecal Abundance of BLSE and the Digestive Microbiota be Predictive of the Risk of Infection in a Carrier Patient?

of ESBL-E bacteremia, demonstrated 5 factors associated with the appearance of E-ESBL-linked bacteremia. These factors were: (i) a history of colonization / infection with ESBL-E, (ii) age 43 years

  • 0 views
  • 03 May, 2021
  • 4 locations
Use of Tamsulosin to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery

Postoperative urinary retention is a frequent complication of spinal surgeries and impacts a large portion of this population which results in increased morbidity as a result of increased number of catheterizations, urinary tract infections (UTIs) and prolonged hospital stays. With the addition of Tamsulosin, the investigators would anticipate a reduction …

  • 10 views
  • 10 Mar, 2022
  • 1 location
Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia

This randomised controlled trial will determine the non-inferiority of stopping empiric antibiotics prior to absolute neutrophil count (ANC) recovery (Early Stopping) versus stopping antibiotics upon ANC recovery (Standard of Care/ Late Stopping) , in children with cancer and high-risk febrile neutropenia (FN).

  • 0 views
  • 12 Dec, 2021
  • 1 location
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI (GAMECHANGER)

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

  • 111 views
  • 19 Feb, 2022
  • 9 locations
Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization (OPSiP)

This is a double-blind randomized placebo controlled trial that will investigate whether the use of three specific species of probiotics taken orally in pregnancy from 25 weeks gestation will reduce the incidence of Group B Streptococcus (GBS) colonization. Participants will take 2 capsules and 1 lozenge per day of either …

Accepts healthy volunteers
  • 20 views
  • 24 Feb, 2022
  • 2 locations
Topical Vancomycin Over Sternal Edge in Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 0 views
  • 12 Sep, 2021
  • 1 location