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Found 61 clinical trials
Evaluation of Prevenar 13's Vaccine Response in Patients Hospitalized in Infectious Disease Department for Sepsis (Vaccis)

treated for an infection (bacteremia, pneumonia, urinary tract infection, etc.). In order to respond to this problem, the investigators have chosen to evaluate the vaccine response to Prevenar 13 (PCV13

bacteremia
pneumonia
pneumococcal
  • 0 views
  • 23 Oct, 2022
  • 1 location
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients (NIPA)

before it occurs. A preventive strategy could in turn reduce the occurrence of complications related to impaired gastrointestinal transit such as ventilator-acquired pneumonia, bacteremia etc. It could

mechanical ventilation
cancer
  • 0 views
  • 13 Apr, 2022
  • 3 locations
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients (TEMODELTA)

with temocillin for (i) complicated urinary tract infection and pyelonephritis (associated or not with bacteremia), or (ii) lower respiratory tract infection, or (iii) abdominal infection, and

abdominal infection
bacteremia
antibiotics
  • 0 views
  • 20 Jun, 2022
  • 1 location
Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock (DéPOH)

De-escalation aims at reducing the use of broad-spectrum antibiotics and therefore the emergence of multidrug-resistant (MDR) pathogens. Observational studies suggested that this strategy seems to be safe. However, there is no adequate, direct evidence showing de-escalation of antimicrobial agents to be effective and safe for onco-hematology patients with sepsis or …

primary cancer
antibiotics
treatment regimen
  • 1 views
  • 01 Feb, 2022
  • 1 location
Antibiotic Prophylaxis in Patients Undergoing GVO (ABX-GV)

We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.

antibiotic therapy
liver disease
antibiotics
endoscopy
gastric varices
  • 3 views
  • 16 Feb, 2022
Functional Non Specific Immunity Monitoring After Kidney Transplantation Using an Interferon Gamma Test

The best renal replacement therapy is kidney transplantation. It improves end-stage renal kidney disease (ESRD) patients quality of life and increases their survival, but still remains risky. Morbidity in kidney transplantation is dominated by two main complications : acute graft rejection and infections. To maintain an accurate balance between rejection …

  • 0 views
  • 22 Jan, 2021
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

Some tumors are difficult to treat with chemotherapy or radiation. One of the reasons is that areas of the tumor do not have many blood vessels, which makes it difficult for drugs to reach those areas. One way that researchers have recently tried to overcome this problem is by injecting …

neutrophil count
tumor cells
liver metastases
doxycycline
chemotherapy drugs
  • 57 views
  • 18 May, 2022
  • 1 location
Blue Light Therapy in Reducing Inflammation During Sepsis

Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome. The ability to modify the host response to the stress of major operations and sepsis carries immense potential to improve patient care. This study …

diverticulitis
sepsis
colon resection
critical illness
a 12
  • 119 views
  • 10 Mar, 2022
  • 1 location
Personalized Immunotherapy in Sepsis (ImmunoSep)

Αim of ImmunoSep is to assess whether personalized adjunctive immunotherapy directed against a state of either fulminant hyper-inflammation or immunoparalysis is able to change sepsis outcomes. Patients will be selected by a panel of biomarkers and laboratory findings and will be allocated to placebo or immunotherapy treatment according to their …

bacteremia
pneumonia
organ failure
  • 0 views
  • 04 Oct, 2022
  • 21 locations
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia (ACCESS)

Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens. Retrospective analysis of observational clinical studies in CAP showed that the addition of macrolides to standard antibiotic therapy conferred a significant survival benefit. The proposed benefit of macrolides is coming …

antimicrobial agent
antibiotics
pneumonia
antibiotic therapy
  • 0 views
  • 19 Apr, 2022
  • 8 locations