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Found 61 clinical trials
Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonization (OPSiP)

This is a double-blind randomized placebo controlled trial that will investigate whether the use of three specific species of probiotics taken orally in pregnancy from 25 weeks gestation will reduce the incidence of Group B Streptococcus (GBS) colonization. Participants will take 2 capsules and 1 lozenge per day of either …

Accepts healthy volunteers
  • 20 views
  • 24 Feb, 2022
  • 2 locations
Topical Vancomycin Paste Over Sternal Edge: Safety and Effect of on Incidence of Sternal Wound Infection After Cardiac Surgery

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin …

  • 0 views
  • 19 Oct, 2022
  • 1 location
Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection (FRANCiS-NF)

This is a comparative study for adult participants with cancer who are suspected to have neutropenic fever (or fever with low neutrophil count) in emergency department. Neutrophil is a kind of defensive white blood cell combating against infection, especially by bacteria and fungi. Low neutrophil can be part of the …

  • 0 views
  • 11 Jul, 2022
  • 1 location
Infectious Diseases in Aged Population (AEQUI)

hospitalizations in this age group result in respiratory infections and bacteraemia and the impact of these infections on the quality of life and disability in aged populations has not been accurately quantified

bacteremia
fever
blood culture
  • 0 views
  • 05 Jun, 2022
  • 16 locations
PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN) (PETERPEN)

the outcome of patients with bacteremia due to cephalosporin-non-susceptible Enterobacteriaceae. The investigators hypothesize that piperacillin-tazobactam is non-inferior to meropenem.

lactam
meropenem
beta-lactam
ceftriaxone
blood culture
  • 23 views
  • 04 Oct, 2022
  • 8 locations
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (BGN)

Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the most common pathogens associated with multidrug resistance and HAIs. These bacteria are of special concern because few therapeutic options are available. Traditionally, the duration of …

antimicrobial agent
antibiotic therapy
antimicrobials
shock
severe infection
  • 0 views
  • 24 Mar, 2022
  • 4 locations
Switch to Oral Antibiotics in Gram-negative Bacteremia (SOAB)

preceding 90 days. Randomization will be stratified by urinary versus non-urinary source of bacteremia. The primary outcome is treatment failure at 90-days with 10% margin for non-inferiority in the 95

  • 77 views
  • 18 Apr, 2022
  • 7 locations
Study to Optimize the Use of New Antibiotics (NEW_SAFE)

degree of follow-up of the recommendations. The audit will be performed on day 0-1 of the prescription. Cohort of bacteremia due to multiresistant microorganisms ("safety" cohort): In order to

bacteremia
antibiotic therapy
carbapenem
antimicrobials
ceftazidime-avibactam
  • 3 views
  • 16 Feb, 2022
  • 13 locations
Carriage Clearance of Emerging Highly Resistant Bacteria in Chronic Dialysis Patients (DIACOBHR)

bacteremia in healthcare establishments in France at less than 1%, and that of Vancomycin Resistant Enterococcus (VRE) belonging to Enterococci Resistant to Glycopeptides (ERG) such as Enterococcus faecium

renal failure
antibiotics
chronic renal failure
dialysis
strain
  • 0 views
  • 27 Apr, 2022
  • 5 locations
Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years

The purpose of this study is to demonstrate the efficacy of 9-valent extraintestinal pathogenic Escherichia coli vaccine (ExPEC9V) compared to placebo in the prevention of the first invasive extraintestinal pathogenic Escherichia coli disease (IED) event caused by ExPEC9V O-serotypes.

Accepts healthy volunteers
  • 144 views
  • 13 Oct, 2022
  • 158 locations