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Found 25 clinical trials
Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock (DOBERMANN)

risk score (≥11 - not in overt shock at hospital admission). Plasma concentrations of N-terminal pro-B-type natriuretic peptide (NTproBNP) as a proxy for development of cardiogenic shock (CS

  • 10 May, 2022
  • 1 location
Nesiritide in Hypertension

the heart. Under physiological conditions of increased myocardial load and resulting myocardial stretch, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) synthesis and secretion

uncontrolled hypertension
systolic blood pressure
myocardial infarction
cardiovascular disease
  • 22 Jan, 2021
  • 3 locations
Telotristat Ethyl for the Treatment of Carcinoid Heart Disease in Patients With Metastatic Neuroendocrine Tumor

This phase III trial compares the effect of telotristat ethyl and the current standard of care somatostatin analog therapy or somatostatin analog therapy alone in treating patients with neuroendocrine tumor that has spread to other places in the body (metastatic). Telotristat ethyl and somatostatin analog therapy may help to control …

  • 13 Jul, 2022
  • 1 location
Race, Natriuretic Peptides and Physiological Perturbations

The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.

Accepts healthy volunteers
  • 25 Feb, 2022
  • 1 location
Conduction System Pacing Versus Biventricular Pacing for Cardiac resYNChronization (CSP-SYNC)

Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) is the cornerstone treatment for heart failure patients with ventricular dyssynchrony. Recently, a new concept, conduction system pacing (CSP) with permanent pacing, including His bundle pacing and left bundle branch pacing, has been proposed as a potential alternative to conventional BiV-CRT. The …

cardiac resynchronization therapy
ejection fraction
atrio-biventricular pacing
heart failure
left bundle branch block
  • 24 Mar, 2022
  • 1 location
Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis

Research Objective:At present, there is no standard therapeutic regimen for monoclonal immunoglobulin light chain (AL) amyloidosis in the world. To compare the efficacy and safety of the regimens between bortezomib-thalidomide-dexamethasone (BTD) and bortezomib-cyclophosphamide-dexamethasone (BCD) in the treatment of AL amyloidosis, so as to provide more clinical evidence for the standard …

bone marrow procedure
  • 26 Jan, 2021
  • 1 location
Pioglitazone for the Treatment of Alcohol Use Disorder (PAUSE)

Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best. Pioglitazone, a medication FDA approved for diabetes, has been shown in pre-clinical studies to reduce alcohol. The proposed study will test the efficacy of …

heavy drinking
  • 01 May, 2022
  • 2 locations
Imaging vs. no Testing in Asymptomatic High-risk Diabetic Patients

The aim of our study was to evaluate 1- and 3-year outcome of alternative imaging strategies in asymptomatic high-risk diabetic patients: functional stress echocardiography combined with coronary flow reserve (CFR) and strain imaging, or computed tomography (CT) angiography with direct visualization of coronary arteries, and no testing at all.

  • 29 Aug, 2021
  • 1 location
Decreasing Patient Anxiety During Revascularization of Chronic Total Coronary Occlusions Using Virtual Reality Glasses. (ReViCTO)

Percutaneous coronary angioplasty on chronic total occlusions is a complex procedure. The possibility of performing these procedures without anesthesia and sedation avoids the risks associated with anesthesia and sedation, but, on the contrary, subjects the patient to pain and anxiety during the procedure. Virtual reality (VR) has been successfully used …

  • 04 Oct, 2022
  • 1 location
Ventilation Modalities and Acute Ischemic Stroke

Acute ischemic stroke is the second leading cause of death and disability, and it is also one of the main reasons for the high cost of health care. The major risk factors for stroke are hypertension, atrial fibrillation, and smoking, which are the main intervention targets for primary stroke prevention. …

  • 04 Oct, 2022
  • 1 location