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Found 7 clinical trials
AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer

The purpose of this study is to find out what effects (good and bad) AZD1775 used in combination with carboplatin and paclitaxel will have on participants and their cancer.

lung cancer
carboplatin/paclitaxel
carboplatin
paclitaxel
lung carcinoma
  • 2 views
  • 18 Apr, 2021
  • 2 locations
Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

neutrophil count
liver metastasis
tyrosine
kinase inhibitor
measurable disease
  • 37 views
  • 17 Sep, 2021
  • 19 locations
AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

This research study is studying an investigational drug as a possible treatment for uterine cancer. The drug involved in this study is: -AZD1775

measurable disease
carcinoma
metastasis
neutrophil count
carcinosarcoma
  • 20 views
  • 17 Jul, 2021
  • 1 location
Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance STAR Study

This phase I trial studies the side effects and best dose of adavosertib when given together with olaparib in treating patients with solid tumors that have spread to other places in the body (advanced) with selected mutations. Adavosertib may stop the growth of tumor cells by blocking some of the …

neutrophil count
liver metastasis
parp inhibitor
cancer
palliative radiation therapy
  • 0 views
  • 24 Jun, 2021
  • 1 location
Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian Fallopian Tube or Primary Peritoneal Cancer

This pilot early phase I trial studies how adavosertib affects the tumor deoxyribonucleic acid (DNA) of patients undergoing surgery for high grade (fast growing or aggressive) ovarian, fallopian tube, or primary peritoneal cancer that has spread to other places in the body (advanced). Certain characteristics in the DNA of these …

cytoreductive surgery
primary peritoneal carcinoma
peritoneal cancer
tubal ligation
neutrophil count
  • 0 views
  • 25 Jan, 2021
  • 9 locations
Adavosertib With or Without Olaparib in Treating Patients With Recurrent Ovarian Primary Peritoneal or Fallopian Tube Cancer

This phase II trial studies how well adavosertib with or without olaparib work in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back (recurrent). Adavosertib and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

serum pregnancy test
olaparib
neutrophil count
liver metastasis
parp inhibitor
  • 8 views
  • 24 Jan, 2021
  • 1 location
Testing the Addition of an Anti-cancer Drug Adavosertib to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

This phase I trial investigates the side effects and best dose of adavosertib and how well it works when given in combination with radiation therapy in treating patients with esophageal or gastroesophageal junction cancer for which no treatment is currently available (incurable). Adavosertib may stop the growth of tumor cells …

  • 0 views
  • 25 Aug, 2021
  • 5 locations