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Found 82 clinical trials
TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

of talazoparib and avelumab. As an exploratory endpoint, the study team will evaluate the immunomodulatory effects of induction talazoparib followed by the combination of talazoparib and avelumab in

measurable disease
advanced breast cancer
  • 32 views
  • 09 Feb, 2022
  • 3 locations
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors (REGOMUNE)

Assessment of the efficacy and safety of Regorafenib and Avelumab in patients with advanced or metastatic solid tumors (ten cohorts), once the Recommanded Phase II Dose (RP2D) has been

cancer chemotherapy
sarcoma
pet scan
EGFR
vascular endothelial growth factor
  • 44 views
  • 04 Mar, 2022
  • 6 locations
Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma

combine neoadjuvant avelumab (a PD-L1 inhibitor) with hypofractionated proton therapy of 20 CGE (cobalt gray equivalent) over 5 fractions followed by planned surgery for recurrent radiation-refractory

central nervous system tumor
proton therapy
blood transfusion
karnofsky performance status
neutrophil count
  • 108 views
  • 04 Mar, 2022
  • 1 location
Neoadjuvant AXITINIB and AVELUMAB for Patients With Localized Clear-cell RCC

a monocenter, open label, single arm, phase II study of the combination of axitinib with avelumab as neoadjuvant therapy in patients with intermediate to high-risk non-metastatic RCC

axitinib
renal function
carcinoma
renal function tests
serum pregnancy test
  • 11 views
  • 03 Mar, 2022
  • 1 location
Axitinib and Avelumab in Treating Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma

This phase II trial studies how well axitinib and avelumab work in treating patients with adenoid cystic carcinoma that has come back or spread to other places in the body. Axitinib may stop the

  • 2 views
  • 15 Feb, 2022
  • 1 location
Avelumab With Axitinib in Persistent or Recurrent Cervical Cancer After Platinum-based Chemotherapy (ALARICE)

This is a single-arm, Simon's 2-stage, proof-of-concept trial. The aim is to evaluate the efficacy and safety of avelumab with axitinib in patients with persistent or recurrent cervical cancer

adenocarcinoma
recurrent cervical cancer
cancer
platinum-based chemotherapy
  • 8 views
  • 14 Mar, 2022
  • 1 location
Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

This study is being done to find the safest dose of DCC-3014 that can be given with avelumab to participants with advanced or metastatic sarcomas that will not cause serious side effects.

myxofibrosarcoma
cancer chemotherapy
leiomyosarcoma
immunomodulators
high grade sarcoma
  • 22 views
  • 16 Mar, 2022
  • 1 location
Maintenance Avelumab Immunotherapy in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma (PULSE)

. Patients with disease progression cannot be included in the PULSE study as this is a maintenance study. After inclusion, Avelumab will be administered at a dose of 10 mg/kg, at a frequency of once

  • 2 views
  • 17 Mar, 2022
  • 2 locations
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers

The study will consist of two parts : In the phase Ib: safety will be assessed in consecutive cohorts of 3 to 6 patients at increasing doses of TG4001 in combination with avelumab

ct scan
cetuximab
kidney function tests
measurable disease
head and neck carcinoma
  • 10 views
  • 23 Mar, 2022
  • 17 locations
Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

This phase I/II trial studies the side effects and best dose of avelumab with M6620 in treating patients with deoxyribonucleic acid (DNA) damage repair (DDR) deficient solid tumors that have

measurable disease
monoclonal antibodies
metastasis
tumor cells
cancer
  • 0 views
  • 24 Nov, 2021
  • 1 location