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Found 106 clinical trials
Safety Tolerability and Efficacy of CLTX-305 in Participants With Autosomal Dominant Hypocalcemia (ADH) Type 1

A Phase IIb open label, dose finding study to evaluate the Safety, Tolerability and Efficacy of CLTX-305 in Autosomal Dominant Hypocalcemia (ADH) Type 1

  • 17 views
  • 26 Jan, 2021
  • 1 location
A Clinical Trial of Water Therapy for Autosomal Dominant Polycystic Kidney Disease

Patients affected by Autosomal Dominant Polycystic Kidney Disease (ADPKD) need a safe and effective long-term treatment regimen. Unfortunately, there are still no disease-specific treatment for

urine osmolality
cyst
glomerular filtration rate
renal disease
treatment regimen
  • 4 views
  • 26 Jan, 2021
  • 1 location
Wishing to Decrease Aquaresis in ADPKD Patients Treated With a V2Ra; the Effect of Regulating Protein and Salt

This study evaluates the effect of regulating salt and protein intake on urinevolume in patients with ADPKD treated with a vasopressine V2 receptor antagonist (V2RA). The investigators hypothesize that changing sodium and protein intake will reduce V2RA-induced polyuria.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Statin Therapy in Patients With Early Stage ADPKD

This study plans to learn if pravastatin is helpful in slowing down the progression of kidney disease in adults with autosomal dominant polycystic kidney disease (ADPKD). Pravastatin has been

pravastatin
glomerular filtration rate
renal disease
investigational drug
  • 2 views
  • 26 Jan, 2021
  • 1 location
Tolvaptan-Octreotide LAR Combination in ADPKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a leading cause of End Stage Kidney Disease (ESKD) worldwide. Elevated levels of 3', 5' - cyclic AMP (cAMP) play a central role in the

vasopressin
octreotide
tubular
cyst
tolvaptan
  • 2 views
  • 25 Jan, 2021
  • 2 locations
Short Term Induction of Ketosis in PKD

Recently, it has been shown that ketose-inducing dietary interventions slow disease progression in animal models of polycystic kidney disease (PKD), even when the state of ketosis is only induced for a short period of time. The present study aims to investigate the effects of short term ketosis on total kidney …

chronic kidney disease
ketose
pkd1
hypertension
renal disease
  • 22 views
  • 25 Jan, 2021
  • 1 location
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene

This study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in subjects receiving a single dose or repeat doses. Single injections will be assessed in an open label way, and repeat injections will be assessed in a double-masked, randomized, sham-controlled fashion.

retinitis
mydriasis
pupil dilation
  • 49 views
  • 26 Jan, 2021
  • 6 locations
Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function

sporadic small vessel diseases (SVDs) and in 30 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

  • 11 views
  • 26 Jan, 2021
  • 5 locations
Epigenetic Regulation of Osteogenesis Imperfecta Severity : miROI Study

Osteogenesis Imperfecta (OI) is a heterogeneous group of rare connective tissue hereditary diseases responsible for fragility and bone deformity. OI is caused by an autosomal dominant mutation

autosomal dominant
col1a1
bone disease
col1a2
genetic disorder
  • 4 views
  • 23 Jan, 2021
  • 2 locations
Effects of Personalized Training at Home Combining Endurance and Resistance in Patients Suffering From Marfan Syndrome

Marfan syndrome (MS) is an autosomal dominant genetic disorder caused by a mutation in the fibrillin-1 gene (FBN1) encoding the protein fibrillin-1. Fibrillin is the main component of

  • 0 views
  • 28 Jan, 2021
  • 1 location