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Found 762 clinical trials
Featured trial
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial

of vaginal atrophy in menopausal women living with HIV. 

  • 79 views
  • 03 Mar, 2021
  • 1 location
Featured trial
Vaginal dryness

Vaginal dryness

  • 960 views
  • 25 Mar, 2021
  • 1 location
Featured trial
Vascular Contributions to Mechanisms and Biomarkers of Alzheimer’s Disease

This study is managed by Temple University Alzheimer’s Center in collaboration with Crozer Keystone Health System. NO drug involvedThe study will evaluate longitudinally whether the presence of cardiovascular (CV) risk factors (particularly hypertension and hyperhomocysteinemia), in an age and gender-matched population including cognitive normal, subjects with mild cognitive impairment (MCI) …

cognitive impairment
cognitive decline
mild cognitive impairment
Accepts healthy volunteers
  • 16 views
  • 09 Sep, 2022
  • 1 location
Featured trial
Proteins and Brain Networks in Atypical Alzheimer's Disease

Participants will take part in 2-4 study visits including detailed history and neurological exam, pen-&-paper cognitive testing, and functional MRI and PET scans designed to help us understand how different forms of Alzheimer's disease affect brain circuits over time.

Accepts healthy volunteers
amyloid
positron emission tomography
  • 53 views
  • 24 Jan, 2022
  • 1 location
Featured trial
New Approaches to Dementia Heterogeneity.

This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …

cancer
aphasia
amyotrophic lateral sclerosis
multiple sclerosis
cognitive impairment
  • 160 views
  • 25 May, 2021
  • 1 location
Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment of Stargardt Disease in Adolescent Subjects

The primary objective of this trial is to assesses the efficacy of tinlarebant in slowing the rate of growth of atrophic lesion(s) in adolescent subjects with STGD1

  • 0 views
  • 21 Sep, 2022
  • 6 locations
Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA) (STEER)

To evaluate the efficacy, safety and tolerability of intrathecal (IT) OAV101 in treatment naive patients with Type 2 spinal muscular atrophy (SMA) who are ≥ 2 to < 18 years of age over a 15

  • 4 views
  • 25 Jul, 2022
  • 4 locations
Different Endoscopic Gastric Cancer Risk Assessments

The Kimura-Takamoto classification established in Japan can observe the extent of gastric atrophy in real-time under endoscopy, and diffuse atrophy also indicates an increased risk of gastric

  • 0 views
  • 28 Jul, 2022
  • 1 location
A Phase 4 Study of Nusinersen (BIIB058) Among Patients With Spinal Muscular Atrophy Who Received Onasemnogene Abeparvovec (RESPOND)

The primary objective of this study is to evaluate the clinical outcomes following treatment with nusinersen in participants with spinal muscular atrophy (SMA) who previously received

nusinersen
gene deletion
  • 2 views
  • 17 Sep, 2022
  • 19 locations
Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy (DEVOTE)

The primary objectives of this study are to examine the clinical efficacy of nusinersen administered intrathecally at higher doses to participants with spinal muscular atrophy (SMA), as measured

muscle atrophy
nusinersen
gene deletion
  • 168 views
  • 11 Jul, 2022
  • 53 locations