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Found 140 clinical trials
Dupilumab Effect on Pruritus Neuro-mechanisms in Patients With Atopic Dermatitis

Primary Objective: Assess change in neuronal architecture following long term treatment with dupilumab in skin biopsies from atopic dermatitis (AD) participants with chronic pruritus Secondary Objectives: Assess change in neuronal architecture following short term treatment with dupilumab and during follow-up in skin biopsies from AD participants with chronic pruritus To …

skin biopsy
eczema
dupilumab
  • 0 views
  • 29 Sep, 2021
  • 3 locations
Tofacitinib for Immune Skin Conditions in Down Syndrome

People with Down syndrome (DS) display widespread immune dysregulation, including several immune skin conditions. This study hypothesizes that pharmacological inhibition of the increased interferon (IFN) signaling seen in DS is safe and could improve associated skin conditions. The study evaluates the safety and efficacy treatment with Tofacitinib, an FDA-approved drug …

dermatitis
vitiligo
tofacitinib
hidradenitis
interferon
  • 60 views
  • 12 Dec, 2021
  • 1 location
Tailored Patient-Provider Communication (TPPC): Evaluating the Impact of TPPC in Dermatology Patients

The impact of tailored patient-provider communication to improve clinical trial recruitment, patient knowledge, and patient engagement will be studied. Tailored patient-provider communication refers to the individualization of patient-provider communication using patients' preferred methods of communication. This involves the utilization of social messaging such as e-mail or text and/or social media …

  • 0 views
  • 09 Apr, 2021
  • 1 location
Staphylococcal Toxins in Atopic Dermatitis and Eczema Herpeticum

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Clinical studies have demonstrated a link between staphylococcal skin colonization and the pathogenesis of AD, but the implication of bacterial virulence factors remains largely uncharacterized. Finally, AD is often associated with herpes simplex skin infections. The aim of this …

  • 0 views
  • 05 Feb, 2021
  • 2 locations
Effects of Treatments on Atopic Dermatitis

Background Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria. Researchers want to study how eczema treatments affect the number and the type of bacteria on the skin. Objectives To study the effect of eczema treatments on skin bacteria. Eligibility Individuals between …

doxycycline
antibiotic therapy
staphylococcus aureus
atopic dermatitis
crusting
  • 246 views
  • 19 Jan, 2022
  • 1 location
BROadband vs Narrowband photoTherapy for Eczema Trial Nested in the CACTI Cohort

Atopic dermatitis (eczema) is a complicated skin condition. In fact, it represents many different underlying problems. These include abnormalities in the skin barrier, the immune system and the

phototherapy
eczema
topical agents
  • 0 views
  • 18 Oct, 2021
  • 1 location
Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases

The molecular mechanisms of action of photo(chemo)therapy in skin diseases are investigated in this study. The phototherapeutic modalities employed include UVB (ultraviolet B), UVA (ultraviolet A), PUVA (psoralen+UVA) and/or extracorporeal photochemotherapy (photopheresis). The study will address whether and how photo(chemo)therapy affects specific biologic pathways in different skin disorders and search …

chemotherapy regimen
puva
psoralen
skin disorder
extracorporeal photopheresis
  • 192 views
  • 21 Jan, 2021
  • 1 location
Intervention in Chronic Pediatric Patients and Their Families.

This project consists of a psychological intervention in patients and their families with different chronic diseases in order to carry out a comparative study between medical pathologies to know which are the protective or risk variables for the adaptation to the disease.

chronic disease
chronic diseases
  • 0 views
  • 24 Jan, 2021
Integrative Body-Mind-Spirit Intervention for Families With Children Suffering From Eczema

This randomized controlled trial aims to examine the efficacy of two integrative body-mind-spirit interventions, compared to a health education active control, in promoting adaptive emotional regulation and quality of life of children with eczema and their parent caregivers in Hong Kong. It also aims to examine the interdependent associations between …

eczema
  • 0 views
  • 17 Sep, 2021
  • 1 location
Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults

This is a double-blind, randomized, vehicle controlled Phase 3 study to evaluate the efficacy and safety of topical tapinarof cream, 1% compared to vehicle control cream in pediatric and adult subjects with atopic dermatitis.

topical agents
  • 0 views
  • 10 Oct, 2021
  • 2 locations