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Found 153 clinical trials
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Skin Barrier Assessment in Pregnancy and at Birth

This is a prospective birth cohort study assessing the role of maternal and environmental factors on the development of allergic diseases in children. Pregnant mothers will be enrolled and we will examine her skin barrier with skin tape strips (STS) and transepidermal water loss (TEWL), along with blood work. We …

eczema
food allergy
wheezing
  • 28 views
  • 25 Jan, 2021
  • 1 location
None
Skin Barrier Abnormalities and Oxidative Stress Response

This is a prospective, single-site controlled observational study designed to comprehensively determine whether children and adults with atopic dermatitis (AD) and food allergy (FA) have skin abnormalities which distinguish them from children with AD without FA, and non-atopic (NA) controls.

allergic rhinitis
asthma
allergen
food allergy
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Molecular Signatures in Inflammatory Skin Disease

This pilot project intends to examine the utility of a systems medicine approach to identify regulatory networks and their perturbation in psoriasis and atopic dermatitis, and to obtain a comprehensive perspective on disease and disease control by integrating and modelling data across multiple cellular levels and time following specific blockade …

skin disorder
upadacitinib
atopy
tralokinumab
baricitinib
  • 31 views
  • 28 Mar, 2021
  • 1 location
None
The Role of Bacterial Toxins in Human Skin Disease

Atopic dermatitis and psoriasis are two skin diseases often associated with bacterial infections and inflammation. Studies indicate that skin cells from these patients may have some changes that make these patients more susceptible to bacterial infections. Inflammatory environment may have an effect on the function of skin cells. The purpose …

skin disorder
atopy
skin biopsy
antihistamines
corticosteroids
  • 269 views
  • 26 Oct, 2021
  • 1 location
None
Bathing Babies and Allergy

Atopic dermatitis (AD) is a chronic allergic skin disease with onset in early childhood and increasing prevalence in Westernized countries. Current well newborn guidelines for washing babies with soap were adopted by U.S. hospitals in the 1970s, before the rise in prevalence of allergic disease and AD (also called eczema). …

skin disorder
atopy
eczema
dermatitis
  • 26 views
  • 21 Jan, 2021
  • 1 location
None
Metabolic Profiling of Immune Responses in Immune-mediated Diseases

Background The immune system is the part of the body that fights infection. Some people have immune deficiencies that cause skin rashes, make them get sick often with infections, or make it difficult for their skin to heal. Researchers want to learn more to better treat conditions that affect immune …

eczema
psoriasis
  • 0 views
  • 19 Aug, 2021
  • 1 location
None
Blood Urine and Tissue Collection for Cutaneous Lymphoma Eczema and Atopic Dermatitis Research

This is a tissue, urine, and blood banking protocol for cutaneous t-cell lymphoma (CTCL), eczema, and atopic dermatitis patients for current and future research.

atopy
skin biopsy
cutaneous t-cell lymphoma
t-cell lymphoma
eczema
  • 75 views
  • 25 Nov, 2021
  • 1 location
None
Inflammatory Cells From Various Pathologies

The objective of this experiment is to develop and validate in vitro methods to isolate inflammatory cells from skin biopsies for quantitative flow cytometry analysis. Real-time polymerase chain reaction (RT-PCR) will also be performed using skin biopsy samples to validate flow cytometry results. Such methods could eventually be used to …

atopy
skin biopsy
atopic dermatitis
serum ige
systemic sclerosis
  • 156 views
  • 29 Aug, 2021
  • 1 location
None
The Role of Filaggrin Mutations and Sensitization Pathways in Allergic Rhinitis and Peanut Allergy

Caucasian male and female participants age 18 years of age and older will be enrolled in this study if they have known birch or peanut allergies or known to be non-atopic. Participants will undergo skin testing to confirm their allergies if not completed in the last 12 months. Medications and …

rhinitis
atopy
atopic diathesis
skin test
sensitisation
  • 14 views
  • 25 Jan, 2021
  • 1 location
None
Extrinsic and Intrinsic Factors in Atopic Dermatitis Upon Systemic Immune Modulation

Currently, patients with moderate to severe atopic dermatitis are treated with dupilumab if unresponsive to topical treatment. However, not all patients who suffer from atopic dermatitis respond similarly to this treatment. Pattern recognition of immune cells (PRI) is an efficient method to screen patients to allow a more personalized therapy. …

dupilumab
eczema
topical agents
  • 0 views
  • 06 Nov, 2021
  • 1 location