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Found 480 clinical trials
Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

This is a single arm, open label, multi centre phase III study to evaluate the efficacy and long term safety of lomitapide in paediatric patients with HoFH receiving stable LLT (including LA, when applicable) comprising of the following phases: Screening Period (starting at Week 12, i.e. ≤12 weeks prior to …

  • 0 views
  • 26 Apr, 2022
  • 11 locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

  • 214 views
  • 26 Jan, 2021
  • 98 locations
Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarography (MICROPROTECT)

Proprotein convertase subtilisin/kexin type 9 inhibitor monoclonal antibodies (anti-PCSK9) significantly reduce the serum LDL-C level, leading to a regression of the coronary epicardial plaque demonstrated by intracoronary ultrasonography (IVUS), as well as cardiovascular events (CV) in patients with atherosclerotic CV disease treated with statin. The impact of PCSK9 inhibition on …

  • 0 views
  • 06 Jun, 2022
  • 1 location
Recipe for Heart Health

The overall objectives of this project are to compare clinical parameters in moderate risk Atherosclerotic Cardiovascular Disease (ASCVD) patients following a Whole Food Plant Based (WFPB) diet

  • 0 views
  • 04 Jun, 2022
  • 1 location
  • 11 views
  • 28 Jul, 2022
  • 30 locations
Survival Benefits of Statins in Breast Cancer Patients (SBSBC)

In this study, we compared the survival benefit of breast cancer patients with dyslipidemia (low and medium risk of ASCVD). The control group used dietary intervention instead of statins

breast cancer
invasive breast cancer
cancer
  • 7 views
  • 09 Feb, 2022
  • 1 location
Comparison of Spectral Photon Counting CT (SPCCT) With Dual Energy CT (DECT) and Magnetic Resonance Imaging (MRI) for Plaque and Lumen Carotid Arteries Evaluation (CAPL)

vulnerable plaques and luminal stenosis in Carotid Atherosclerosis patients compared to DECT (Dual Energy CT) and MRI (Magnetic Resonance Imaging) which are used in current practice

  • 0 views
  • 29 May, 2022
  • 1 location
Short Term Choline and Cardiovascular Health

Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to

atherosclerosis
trimethylamine n-oxide
cardiovascular disease
Accepts healthy volunteers
  • 21 views
  • 16 Mar, 2022
  • 1 location
Choline Supplementation and Cardiovascular Health

Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to

atherosclerosis
trimethylamine n-oxide
cardiovascular disease
Accepts healthy volunteers
  • 94 views
  • 24 Apr, 2022
  • 1 location
Choline and Cardiometabolic Health

Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to

Accepts healthy volunteers
  • 0 views
  • 18 Apr, 2022
  • 1 location